Insecticide Resistance in Mosquitoes: Impact, Mechanisms, and Research Directions

Mosquito-borne diseases, the most well known of which is malaria, are among the leading causes of human deaths worldwide. Vector control is a very important part of the global strategy for management of mosquito-associated diseases, and insecticide application is the most important component in this...

Full description

Saved in:
Bibliographic Details
Published in:Annual Review of Entomology 2015-01, Vol.60 (1), p.537-559
Main Author: Liu, Nannan
Format: Article
Language:English
Subjects:
Animals
Culicidae
Culicidae - drug effects
Culicidae - genetics
functional study
Gene Expression Regulation
Insecticide Resistance
Insecticides - pharmacology
metabolic detoxification
resistance-gene regulation
target-site insensitivity
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mosquito-borne diseases, the most well known of which is malaria, are among the leading causes of human deaths worldwide. Vector control is a very important part of the global strategy for management of mosquito-associated diseases, and insecticide application is the most important component in this effort. However, mosquito-borne diseases are now resurgent, largely because of the insecticide resistance that has developed in mosquito vectors and the drug resistance of pathogens. A large number of studies have shown that multiple, complex resistance mechanisms-in particular, increased metabolic detoxification of insecticides and decreased sensitivity of the target proteins-or genes are likely responsible for insecticide resistance. Gene overexpression and amplification, and mutations in protein-coding-gene regions, have frequently been implicated as well. However, no comprehensive understanding of the resistance mechanisms or regulation involved has yet been developed. This article reviews current knowledge of the molecular mechanisms, genes, gene interactions, and gene regulation governing the development of insecticide resistance in mosquitoes and discusses the potential impact of the latest research findings on the basic and practical aspects of mosquito resistance research.
ISSN:0066-4170
1545-4487
DOI:10.1146/annurev-ento-010814-020828