Comparative Analysis of Intestinal Tract Models

The human gut is a complex ecosystem occupied by a diverse microbial community. Modulation of this microbiota impacts health and disease. The definitive way to investigate the impact of dietary intervention on the gut microbiota is a human trial. However, human trials are expensive and can be diffic...

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Bibliographic Details
Published in:Annual review of food science and technology 2015-04, Vol.6 (1), p.329-350
Main Authors: Williams, C.F, Walton, G.E, Jiang, L, Plummer, S, Garaiova, I, Gibson, G.R
Format: Article
Language:English
Subjects:
Animals
gut microbiome
Humans
In Vitro Techniques
intervention studies
intestinal models
Intestines - anatomy & histology
Intestines - microbiology
Microbiota
Models, Anatomic
Models, Animal
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Summary:The human gut is a complex ecosystem occupied by a diverse microbial community. Modulation of this microbiota impacts health and disease. The definitive way to investigate the impact of dietary intervention on the gut microbiota is a human trial. However, human trials are expensive and can be difficult to control; thus, initial screening is desirable. Utilization of a range of in vitro and in vivo models means that useful information can be gathered prior to the necessity for human intervention. This review discusses the benefits and limitations of these approaches.
ISSN:1941-1413
1941-1421
DOI:10.1146/annurev-food-022814-015429