EVOLVING TREATMENT STRATEGIES FOR INFLAMMATORY BOWEL DISEASE

Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel diseases characterized by dysregulated intestinal immune responses in genetically susceptible hosts. Conventional approaches to the medical therapy of ulcerative colitis and Crohn's disease can now be directed at eith...

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Bibliographic Details
Published in:Annual review of medicine 2001-01, Vol.52 (1), p.299-318
Main Authors: Hanauer, Stephen B, Dassopoulos, Themistocles
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Azathioprine - pharmacology
Azathioprine - therapeutic use
biologic therapies
Biological and medical sciences
Crohn's disease
Cyclosporins - pharmacology
Cyclosporins - therapeutic use
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunosuppressive Agents - pharmacology
Immunosuppressive Agents - therapeutic use
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - etiology
Inflammatory Bowel Diseases - immunology
infliximab
Medical sciences
Mesalamine - pharmacology
Mesalamine - therapeutic use
Methotrexate - pharmacology
Methotrexate - therapeutic use
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - pharmacology
Mycophenolic Acid - therapeutic use
Other diseases. Semiology
Steroids
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tacrolimus - pharmacology
Tacrolimus - therapeutic use
ulcerative colitis
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Summary:Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel diseases characterized by dysregulated intestinal immune responses in genetically susceptible hosts. Conventional approaches to the medical therapy of ulcerative colitis and Crohn's disease can now be directed at either induction or maintenance of remission to improve therapeutic efficacy while minimizing complications. Newer approaches have expanded the utility of conventional therapies by improving both safety and efficacy and highlight the importance of specific targets along the immunoinflammatory pathways. The combination of conventional and novel approaches now offers the potential of modifying the natural history of these diseases.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.med.52.1.299