The Role of nutrition in toxicology

A review of relationships between nutrition and toxicology focuses on the effect of nutritional status on the toxicity of drugs and environmental chemicals (xenobiotics), and on the additional nutritional demands resulting from exposure to drugs and environmenal chemicals. Current research findings...

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Bibliographic Details
Published in:Annual review of nutrition 1981-01, Vol.1 (1), p.207-234
Main Authors: Parke, Dennis V, Ioannides, Costas
Format: Article
Language:English
Subjects:
Animals
Biotransformation
Diet
Dietary Fats - pharmacology
Drug-Related Side Effects and Adverse Reactions
Enzyme Induction - drug effects
Folic Acid Deficiency - metabolism
Humans
Inactivation, Metabolic
Microsomes - enzymology
Microsomes, Liver - enzymology
Minerals - pharmacology
Mixed Function Oxygenases - metabolism
Neoplasms - etiology
Nutritional Physiological Phenomena
Protein-Energy Malnutrition - metabolism
Toxicology
Toxins, Biological - metabolism
Vitamins - pharmacology
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Summary:A review of relationships between nutrition and toxicology focuses on the effect of nutritional status on the toxicity of drugs and environmental chemicals (xenobiotics), and on the additional nutritional demands resulting from exposure to drugs and environmenal chemicals. Current research findings are discussed on the effect of micronutrients (vitamins A, B, C, and D; iron; folate) on microsomal metabolism and chemical toxicity. Aspects of nutritional deficiencies (vitamins A and C, protein, dietary lipids), chemical toxicity, disease states (atherosclerosis, cancer), and therapeutic nutrition are described. Information on metabolic detoxification, dietary induction of microsomal enzymes (mixed function oxides (MFO)), the role of lipids in MFO function, and the relationships of protein-calorie malnutrition, MFO, and chemical toxicity also is discussed. (wz)
ISSN:0199-9885
1545-4312
DOI:10.1146/annurev.nu.01.070181.001231