Critical Periods in Vision Revisited

For four decades, investigations of the biological basis of critical periods in the developing mammalian visual cortex were dominated by study of the consequences of altered early visual experience in cats and nonhuman primates. The neural deficits thus revealed also provided insight into the origin...

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Bibliographic Details
Published in:Annual review of vision science 2022-09, Vol.8 (1), p.291-321
Main Authors: Mitchell, Donald E, Maurer, Daphne
Format: Article
Language:English
Subjects:
amblyopia
binocular vision
ocular dominance
visual acuity
visual cortex
visual deprivation
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Summary:For four decades, investigations of the biological basis of critical periods in the developing mammalian visual cortex were dominated by study of the consequences of altered early visual experience in cats and nonhuman primates. The neural deficits thus revealed also provided insight into the origin and neural basis of human amblyopia that in turn motivated additional studies of humans with abnormal early visual input. Recent human studies point to deficits arising from alterations in all visual cortical areas and even in nonvisual cortical regions. As the new human data accumulated in parallel with a near-complete shift toward the use of rodent animal models for the study of neural mechanisms, it is now essential to review the human data and the earlier animal data obtained from cats and monkeys to infer general conclusions and to optimize future choice of the most appropriate animal model.
ISSN:2374-4642
2374-4650
DOI:10.1146/annurev-vision-090721-110411