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Development of a Polypyrrole-Modified Graphite Electrode for Acetaminophen Determination
Nowadays, acetaminophen commonly known as paracetamol , has been one of the most used drugs for pain treatment. By now, there have been reported only two official methods for the determination of this pharmaceutical active: HPLC and direct titration. Other techniques have been also reported in liter...
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Published in: | ECS transactions 2019-10, Vol.94 (1), p.53-62 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | Nowadays, acetaminophen commonly known as paracetamol , has been one of the most used drugs for pain treatment. By now, there have been reported only two official methods for the determination of this pharmaceutical active: HPLC and direct titration. Other techniques have been also reported in literature, like: spectroscopy, capillary electrophoresis and electrochemical techniques, including biosensors, microelectrodes and modified electrodes, these last have additional advantages like economy, fast and reliable response, and high selective to acetaminophen . In the present work an electroanalytical low-cost technique is proposed for the selective quantification of acetaminophen determination. This selectivity is achieved by molecular imprinting of acetaminophen on a polypyrrole matrix, electrochemically sintetized on the surface of a graphite electrode. The polypyrrole matrix acts as a selective preconcentration material for acetaminophen wich is latter determined by Square Wave Voltammetry in a separate clean electrolyte. |
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ISSN: | 1938-5862 1938-6737 1938-6737 1938-5862 |
DOI: | 10.1149/09401.0053ecst |