Self-Reporting Molecularly Imprinted Polymer-Based Electrochemical Sensors for Structurally Similar Analytes

Molecularly imprinted polymers (MIPs) having inherent redox activity is developed for reagent-free electrochemical detection of steroid hormone biomarker cortisol. Ferrocenylmethyl methacrylate and acrylic acid were used as redox and functional monomers, respectively. Free radical initiated co-polym...

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Bibliographic Details
Published in:ECS transactions 2022-04, Vol.107 (1), p.16673-16678
Main Authors: Magudeeswaran, Vignesh, Velayutham, Jayasudha, Paramasivam, Sriraja Subhasri, Karuppaiah, Gopi, Mariappan, Siva ANANTH, Manickam, Pandiaraj
Format: Article
Language:English
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Summary:Molecularly imprinted polymers (MIPs) having inherent redox activity is developed for reagent-free electrochemical detection of steroid hormone biomarker cortisol. Ferrocenylmethyl methacrylate and acrylic acid were used as redox and functional monomers, respectively. Free radical initiated co-polymerization process was performed in the presence of cortisol as a template to create electroactive MIPs. The copolymerized ferrocenylmethyl methacrylate network provided the redox-active and self-reporting electrochemical platform for detecting redox-inactive biomarkers without using any additional reagents. Cortisol is chosen as the model analyte to evaluate the performance of the self-reporting molecular recognition property. The self-reporting MIPs allowed the quantitative detection of cortisol (as low as 0.5 ng) in the presence of other structurally similar steroid hormones.
ISSN:1938-5862
1938-6737
DOI:10.1149/10701.16673ecst