Influence of Surface Conditions on the Adsorption Process of Bovine Serum Albumin (BSA) on CoCrMo Biomedical Alloy

• Main Authors: Valero Vidal, Carlos, Igual-Muñoz, Anna
• Format: Conference Proceeding
• Language: English
• ISSN: 1938-5862; 1938-6737
• DOI: 10.1149/1.3407557

CoCrMo alloys are biocompatible materials widely used for orthopaedic implants. The biocompatibility of CoCrMo alloy is closely related to its excellent corrosion resistance, imparted by a passive oxide film that forms spontaneously on the alloy surface. The adsorption of organic species present in the synovial fluids may attach with this passive film and modify their surface reactions. BSA adsorption on CoCrMo surface was studied in order to determine the mechanism of protein adsorption at different surface conditions and passivation times in phosphate buffered solution (PBS). At Open Circuit Potential (OCP), adsorption kinetics were influenced by surface passivation when passivation time was lower than 1 hour, whereas, at higher passivation times, no apparent modification in the kinetic mechanisms of adsorption was observed. On the other hand, at a passive applied potential, the BSA addition decreased the passivation kinetics of the process at all the passivation times.