ANG II controls Na+-K+(NH+4)-2Cl- cotransport via 20-HETE and PKC in medullary thick ascending limb

1  Physiologie et Endocrinologie Cellulaire Rénale, Institut National de la Santé et de la Recherche Médicale Unité 356, Université Pierre et Marie Curie and Hôpital Broussais, 75270 Paris Cedex 06, France; and 2  Department of Internal Medicine and Molecular Genetics, University of Cincinnati Schoo...

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Published in:American Journal of Physiology: Cell Physiology 1998-04, Vol.274 (4), p.C1047-C1056
Main Authors: Amlal, Hassane, LeGoff, Christian, Vernimmen, Catherine, Soleimani, Manoocher, Paillard, Michel, Bichara, Maurice
Format: Article
Language:English
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Summary:1  Physiologie et Endocrinologie Cellulaire Rénale, Institut National de la Santé et de la Recherche Médicale Unité 356, Université Pierre et Marie Curie and Hôpital Broussais, 75270 Paris Cedex 06, France; and 2  Department of Internal Medicine and Molecular Genetics, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 Cell pH was monitored in medullary thick ascending limbs to determine effects of ANG II on Na + -K + (NH + 4 )-2Cl cotransport. ANG II at 10 16 to 10 12 M inhibited 30-50% ( P  
ISSN:0363-6143
1522-1563
DOI:10.1152/ajpcell.1998.274.4.c1047