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Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats
1 Section of Endocrinology and Metabolism, McGuire Veterans Administration Medical Center and 2 Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23249 The interrelationship between insulin and leptin resistance in young Fischer 344 (F344) rats was studied. Young F3...
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| Published in: | American journal of physiology: endocrinology and metabolism 2002-03, Vol.282 (3), p.E626-E633 |
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| cited_by | cdi_FETCH-LOGICAL-c453t-bb86306352122c75103b5f1965545cfb69edc902a518793e877949da5798dc4e3 |
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| cites | cdi_FETCH-LOGICAL-c453t-bb86306352122c75103b5f1965545cfb69edc902a518793e877949da5798dc4e3 |
| container_end_page | E633 |
| container_issue | 3 |
| container_start_page | E626 |
| container_title | American journal of physiology: endocrinology and metabolism |
| container_volume | 282 |
| creator | Levy, James R Davenport, Byrd Clore, John N Stevens, Wayne |
| description | 1 Section of Endocrinology and Metabolism, McGuire Veterans
Administration Medical Center and 2 Medical College of Virginia,
Virginia Commonwealth University, Richmond, Virginia 23249
The
interrelationship between insulin and leptin resistance in young
Fischer 344 (F344) rats was studied. Young F344 and Sprague-Dawley (SD)
rats were fed regular chow. F344 animals had two- to threefold higher
insulin and triglyceride concentrations and increased stores of
triglycerides within liver and muscle. F344 animals gained more body
fat. Both acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase I
gene expression were 20-50% less in F344 animals than in
age-matched SD animals. Peroxisome proliferator-activated receptor-
gene expression was reduced in 70-day-old F344 animals. Finally,
resistin gene expression was similar in 70-day-old SD and F344 animals. Resistin gene expression increased fivefold in F344 animals and twofold
in SD animals from 70 to 130 days, without a change in insulin
sensitivity. We conclude that young F344 animals have both insulin and
leptin resistance, which may lead to diminished fatty oxidation and
accumulation of triglycerides in insulin-sensitive target tissues. We
did not detect a role for resistin in the etiology of insulin
resistance in F344 animals.
Fischer 344 rats; acyl-coenzyme A oxidase; carnitine
palmitoyltransferase I; peroxisome proliferator-activated receptor- |
| doi_str_mv | 10.1152/ajpendo.00346.2001 |
| format | article |
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Administration Medical Center and 2 Medical College of Virginia,
Virginia Commonwealth University, Richmond, Virginia 23249
The
interrelationship between insulin and leptin resistance in young
Fischer 344 (F344) rats was studied. Young F344 and Sprague-Dawley (SD)
rats were fed regular chow. F344 animals had two- to threefold higher
insulin and triglyceride concentrations and increased stores of
triglycerides within liver and muscle. F344 animals gained more body
fat. Both acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase I
gene expression were 20-50% less in F344 animals than in
age-matched SD animals. Peroxisome proliferator-activated receptor-
gene expression was reduced in 70-day-old F344 animals. Finally,
resistin gene expression was similar in 70-day-old SD and F344 animals. Resistin gene expression increased fivefold in F344 animals and twofold
in SD animals from 70 to 130 days, without a change in insulin
sensitivity. We conclude that young F344 animals have both insulin and
leptin resistance, which may lead to diminished fatty oxidation and
accumulation of triglycerides in insulin-sensitive target tissues. We
did not detect a role for resistin in the etiology of insulin
resistance in F344 animals.
Fischer 344 rats; acyl-coenzyme A oxidase; carnitine
palmitoyltransferase I; peroxisome proliferator-activated receptor-</description><identifier>ISSN: 0193-1849</identifier><identifier>EISSN: 1522-1555</identifier><identifier>DOI: 10.1152/ajpendo.00346.2001</identifier><identifier>PMID: 11832366</identifier><language>eng</language><publisher>United States</publisher><subject>Acyl-CoA Oxidase ; Animals ; Blood Glucose - analysis ; Body Composition ; Body Weight ; Carnitine O-Palmitoyltransferase - genetics ; Drug Resistance ; Gene Expression ; Glucose Tolerance Test ; Hormones, Ectopic - genetics ; Insulin - analysis ; Insulin - blood ; Insulin Resistance - genetics ; Kinetics ; Leptin - blood ; Leptin - pharmacology ; Lipid Metabolism ; Lipids - blood ; Liver - chemistry ; Muscle, Skeletal - chemistry ; Nerve Growth Factor ; Oxidoreductases - genetics ; Proteins ; Rats ; Rats, Inbred F344 ; Rats, Sprague-Dawley ; Receptors, Cytoplasmic and Nuclear - genetics ; Resistin ; Transcription Factors - genetics ; Triglycerides - analysis</subject><ispartof>American journal of physiology: endocrinology and metabolism, 2002-03, Vol.282 (3), p.E626-E633</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-bb86306352122c75103b5f1965545cfb69edc902a518793e877949da5798dc4e3</citedby><cites>FETCH-LOGICAL-c453t-bb86306352122c75103b5f1965545cfb69edc902a518793e877949da5798dc4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11832366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levy, James R</creatorcontrib><creatorcontrib>Davenport, Byrd</creatorcontrib><creatorcontrib>Clore, John N</creatorcontrib><creatorcontrib>Stevens, Wayne</creatorcontrib><title>Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats</title><title>American journal of physiology: endocrinology and metabolism</title><addtitle>Am J Physiol Endocrinol Metab</addtitle><description>1 Section of Endocrinology and Metabolism, McGuire Veterans
Administration Medical Center and 2 Medical College of Virginia,
Virginia Commonwealth University, Richmond, Virginia 23249
The
interrelationship between insulin and leptin resistance in young
Fischer 344 (F344) rats was studied. Young F344 and Sprague-Dawley (SD)
rats were fed regular chow. F344 animals had two- to threefold higher
insulin and triglyceride concentrations and increased stores of
triglycerides within liver and muscle. F344 animals gained more body
fat. Both acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase I
gene expression were 20-50% less in F344 animals than in
age-matched SD animals. Peroxisome proliferator-activated receptor-
gene expression was reduced in 70-day-old F344 animals. Finally,
resistin gene expression was similar in 70-day-old SD and F344 animals. Resistin gene expression increased fivefold in F344 animals and twofold
in SD animals from 70 to 130 days, without a change in insulin
sensitivity. We conclude that young F344 animals have both insulin and
leptin resistance, which may lead to diminished fatty oxidation and
accumulation of triglycerides in insulin-sensitive target tissues. We
did not detect a role for resistin in the etiology of insulin
resistance in F344 animals.
Fischer 344 rats; acyl-coenzyme A oxidase; carnitine
palmitoyltransferase I; peroxisome proliferator-activated receptor-</description><subject>Acyl-CoA Oxidase</subject><subject>Animals</subject><subject>Blood Glucose - analysis</subject><subject>Body Composition</subject><subject>Body Weight</subject><subject>Carnitine O-Palmitoyltransferase - genetics</subject><subject>Drug Resistance</subject><subject>Gene Expression</subject><subject>Glucose Tolerance Test</subject><subject>Hormones, Ectopic - genetics</subject><subject>Insulin - analysis</subject><subject>Insulin - blood</subject><subject>Insulin Resistance - genetics</subject><subject>Kinetics</subject><subject>Leptin - blood</subject><subject>Leptin - pharmacology</subject><subject>Lipid Metabolism</subject><subject>Lipids - blood</subject><subject>Liver - chemistry</subject><subject>Muscle, Skeletal - chemistry</subject><subject>Nerve Growth Factor</subject><subject>Oxidoreductases - genetics</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Cytoplasmic and Nuclear - genetics</subject><subject>Resistin</subject><subject>Transcription Factors - genetics</subject><subject>Triglycerides - analysis</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp1kEtr4zAURsUwZZI-_sAsBq1m51RXL1vLISRtIdBF27WQ7etExa-RbKb593WatFkNXBBcne_jcgj5CWwBoPite-2xLbsFY0LqBWcMvpH59METUEp9J3MGRiSQSTMjlzG-MsZSJfkPMgPIBBdaz8nTxve-pA0OLu9qHxvq2pIGjD4OvqVbbJHiWz8tou9a6g8Tx9q3yZFx7UDXPhY7DFRISYMb4jW5qFwd8eb0XpGX9ep5eZ9sHu8eln82SSGVGJI8z7RgWigOnBepAiZyVYHRSklVVLk2WBaGcacgS43ALE2NNKVTqcnKQqK4Ir-PvX3o_o4YB9tMl2Bduxa7MdoUpDYgYAL5ESxCF2PAyvbBNy7sLTB7UGlPKu2HSntQOYV-ndrHvMHyHDm5m4DkCOz8dvfPB7T9bj9Zqrvt_quQZ9wKu9L8wJv_8-uxrp_xbfgMnnO2LyvxDgLhlWc</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Levy, James R</creator><creator>Davenport, Byrd</creator><creator>Clore, John N</creator><creator>Stevens, Wayne</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats</title><author>Levy, James R ; Davenport, Byrd ; Clore, John N ; Stevens, Wayne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-bb86306352122c75103b5f1965545cfb69edc902a518793e877949da5798dc4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acyl-CoA Oxidase</topic><topic>Animals</topic><topic>Blood Glucose - analysis</topic><topic>Body Composition</topic><topic>Body Weight</topic><topic>Carnitine O-Palmitoyltransferase - genetics</topic><topic>Drug Resistance</topic><topic>Gene Expression</topic><topic>Glucose Tolerance Test</topic><topic>Hormones, Ectopic - genetics</topic><topic>Insulin - analysis</topic><topic>Insulin - blood</topic><topic>Insulin Resistance - genetics</topic><topic>Kinetics</topic><topic>Leptin - blood</topic><topic>Leptin - pharmacology</topic><topic>Lipid Metabolism</topic><topic>Lipids - blood</topic><topic>Liver - chemistry</topic><topic>Muscle, Skeletal - chemistry</topic><topic>Nerve Growth Factor</topic><topic>Oxidoreductases - genetics</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Cytoplasmic and Nuclear - genetics</topic><topic>Resistin</topic><topic>Transcription Factors - genetics</topic><topic>Triglycerides - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levy, James R</creatorcontrib><creatorcontrib>Davenport, Byrd</creatorcontrib><creatorcontrib>Clore, John N</creatorcontrib><creatorcontrib>Stevens, Wayne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levy, James R</au><au>Davenport, Byrd</au><au>Clore, John N</au><au>Stevens, Wayne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol Endocrinol Metab</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>282</volume><issue>3</issue><spage>E626</spage><epage>E633</epage><pages>E626-E633</pages><issn>0193-1849</issn><eissn>1522-1555</eissn><abstract>1 Section of Endocrinology and Metabolism, McGuire Veterans
Administration Medical Center and 2 Medical College of Virginia,
Virginia Commonwealth University, Richmond, Virginia 23249
The
interrelationship between insulin and leptin resistance in young
Fischer 344 (F344) rats was studied. Young F344 and Sprague-Dawley (SD)
rats were fed regular chow. F344 animals had two- to threefold higher
insulin and triglyceride concentrations and increased stores of
triglycerides within liver and muscle. F344 animals gained more body
fat. Both acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase I
gene expression were 20-50% less in F344 animals than in
age-matched SD animals. Peroxisome proliferator-activated receptor-
gene expression was reduced in 70-day-old F344 animals. Finally,
resistin gene expression was similar in 70-day-old SD and F344 animals. Resistin gene expression increased fivefold in F344 animals and twofold
in SD animals from 70 to 130 days, without a change in insulin
sensitivity. We conclude that young F344 animals have both insulin and
leptin resistance, which may lead to diminished fatty oxidation and
accumulation of triglycerides in insulin-sensitive target tissues. We
did not detect a role for resistin in the etiology of insulin
resistance in F344 animals.
Fischer 344 rats; acyl-coenzyme A oxidase; carnitine
palmitoyltransferase I; peroxisome proliferator-activated receptor-</abstract><cop>United States</cop><pmid>11832366</pmid><doi>10.1152/ajpendo.00346.2001</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0193-1849 |
| ispartof | American journal of physiology: endocrinology and metabolism, 2002-03, Vol.282 (3), p.E626-E633 |
| issn | 0193-1849 1522-1555 |
| language | eng |
| recordid | cdi_crossref_primary_10_1152_ajpendo_00346_2001 |
| source | American Physiological Society Free |
| subjects | Acyl-CoA Oxidase Animals Blood Glucose - analysis Body Composition Body Weight Carnitine O-Palmitoyltransferase - genetics Drug Resistance Gene Expression Glucose Tolerance Test Hormones, Ectopic - genetics Insulin - analysis Insulin - blood Insulin Resistance - genetics Kinetics Leptin - blood Leptin - pharmacology Lipid Metabolism Lipids - blood Liver - chemistry Muscle, Skeletal - chemistry Nerve Growth Factor Oxidoreductases - genetics Proteins Rats Rats, Inbred F344 Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear - genetics Resistin Transcription Factors - genetics Triglycerides - analysis |
| title | Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats |
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