Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise

1  Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1; and 2  Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5 This study investigated the effect of reduced free fatty acid (FFA) availability on pyruvate dehydrogenase act...

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Published in:American journal of physiology: endocrinology and metabolism 2003-03, Vol.284 (3), p.E589-E596
Main Authors: Stellingwerff, Trent, Watt, Matthew J, Heigenhauser, G. J. F, Spriet, Lawrence L
Format: Article
Language:English
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Summary:1  Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1; and 2  Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5 This study investigated the effect of reduced free fatty acid (FFA) availability on pyruvate dehydrogenase activation (PDHa) and carbohydrate metabolism during moderate aerobic exercise. Eight active male subjects cycled for 40 min at 55% O 2 peak on two occasions. During one trial, subjects ingested 20 mg/kg body mass of the antilipolytic drug nicotinic acid (NA) during the hour before exercise to reduce FFA. Nothing was ingested in the control trial (CON). Blood and expired gas measurements were obtained throughout the trials, and muscle biopsy samples were obtained immediately before exercise and at 5, 20, and 40 min of exercise. Plasma FFA were lower in the NA trial (0.13 ± 0.01   vs. 0.48 ± 0.03 mM, P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00418.2002