beta -Adrenergic regulation of lipolysis and blood flow in human skeletal muscle in vivo

1  Department of Medicine and Research Center, 2  Department of Vascular Surgery, Huddinge Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden Little is known about the regulation of catecholamine-stimulated lipolysis in human skeletal muscle. Therefore, -adrenergic regulation of lipolysis and...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 1998-12, Vol.275 (6), p.E909-E916
Main Authors: Hagstrom-Toft, Eva, Enoksson, Staffan, Moberg, Erik, Bolinder, Jan, Arner, Peter
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1  Department of Medicine and Research Center, 2  Department of Vascular Surgery, Huddinge Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden Little is known about the regulation of catecholamine-stimulated lipolysis in human skeletal muscle. Therefore, -adrenergic regulation of lipolysis and blood flow was investigated in healthy subjects in vivo by use of microdialysis of the gastrocnemius muscle. First, during a hypoglycemic, hyperinsulinemic clamp, which induces a lipolytic response in skeletal muscle tissue, the muscle was locally perfused with -adrenoceptor blocking agents. Perfusion with nonselective (propranolol) and 2 -selective (ICI-118551) blocking agents counteracted the hypoglycemia-induced lipolysis ( P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.1998.275.6.e909