Cytokines induce NF-κB in activated but not in quiescent rat hepatic stellate cells

The hepatic stellate cell (HSC), after a fibrogenic stimulus, is transformed from a quiescent to an activated phenotype, including the induction of responsiveness to a variety of agonists. We investigated the activation of nuclear factor-κB (NF-κB) and the expression of the NF-κB-responsive genes in...

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Published in:American journal of physiology: Gastrointestinal and liver physiology 1998-08, Vol.275 (2), p.G269-G278
Main Authors: Hellerbrand, C, Jobin, C, Licato, L L, Sartor, R B, Brenner, D A
Format: Article
Language:English
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Summary:The hepatic stellate cell (HSC), after a fibrogenic stimulus, is transformed from a quiescent to an activated phenotype, including the induction of responsiveness to a variety of agonists. We investigated the activation of nuclear factor-κB (NF-κB) and the expression of the NF-κB-responsive genes intercellular adhesion molecule 1 (ICAM-1) and macrophage inflammatory protein-2 (MIP-2) in freshly isolated and culture-activated HSC by tumor necrosis factor-α (TNF-α) or interleukin-1β. Inhibitor-κB was rapidly (
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.1998.275.2.G269