Experimental colitis increases blood-brain barrier permeability in rabbits

Extraintestinal manifestations of inflammatory bowel disease are numerous. This study examined the effects of two models of acute colitis on cerebral blood flow (CBF) and permeability of the blood-brain barrier in rabbits. CBF (measured with radiolabeled microspheres), or the extraction ratio or per...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 1999-05, Vol.276 (5), p.G1174-G1180
Main Authors: Hathaway, Christopher A., Appleyard, Caroline B., Percy, William H., Williams, John L.
Format: Article
Language:English
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Summary:Extraintestinal manifestations of inflammatory bowel disease are numerous. This study examined the effects of two models of acute colitis on cerebral blood flow (CBF) and permeability of the blood-brain barrier in rabbits. CBF (measured with radiolabeled microspheres), or the extraction ratio or permeability-surface area (PS) product of the blood-brain barrier to fluorescein and FITC-dextran, was measured 48 h after colitis induction with acetic acid (HAc) or trinitrobenzene sulfonic acid (TNBS). PS product for fluorescein increased ( P 
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.1999.276.5.G1174