Arterial distensibility: acute changes following dynamic exercise in normal subjects

1  Department of Cardiology and 2  Department of Diagnostic Radiology, Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine; and 3  Department of Nuclear Cardiology, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, United Kingdom...

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Published in:American journal of physiology. Heart and circulatory physiology 2003-03, Vol.284 (3), p.H970-H978
Main Authors: Naka, Katerina K, Tweddel, Ann C, Parthimos, Dimitris, Henderson, Andrew, Goodfellow, Jonathan, Frenneaux, Michael P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arm - blood supply
Arteries - physiology
Blood Pressure - physiology
Exercise Test
Female
Heart Rate - physiology
Humans
Leg - blood supply
Male
Middle Aged
Models, Cardiovascular
Physical Exertion - physiology
Pulsatile Flow - physiology
Reference Values
Time Factors
Vasodilation - physiology
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Summary:1  Department of Cardiology and 2  Department of Diagnostic Radiology, Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine; and 3  Department of Nuclear Cardiology, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, United Kingdom The time course of acute changes in large artery distensibility immediately and for 60 min following maximum treadmill exercise in normal subjects was characterized by simultaneously measuring upper and lower limb pulse wave velocity (PWV). A new oscillometric technique was used, which has proven to be sensitive to changes in distensibility induced by acute changes in vascular tone independently of blood pressure. The observed changes in PWV are attributable to changes in vascular tone corresponding to recovery from a systemic net constrictor response and a local net dilator response to exercise with persisting postexercise vasodilatation. They are inadequately explained by associated changes in blood pressure and cannot be attributed to changes in heart rate or viscosity. Modeled as a system of n coupled linear differential equations, the minimum (and adequate) order required to reproduce these patterns was n  = 1 for the upper and n  = 2 for the exercising lower limb. The economy of the solution suggests entrainment among the multiple interactive mechanisms governing vasomotor control. exercise physiology; large arteries; pulse wave velocity; vascular responses
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00529.2002