Determinants of action potential initiation in isolated rabbit atrial and ventricular myocytes

Todd Franklin Cardiac Research Laboratory, The Children's Heart Center, Department of Pediatrics, Emory University, Atlanta, Georgia 30322 Action potential conduction through the atrium and the ventricle of the heart depends on the membrane properties of the atrial and ventricular cells, partic...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1998-06, Vol.274 (6), p.H1902-H1913
Main Authors: Golod, David A, Kumar, Rajiv, Joyner, Ronald W
Format: Article
Language:English
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Summary:Todd Franklin Cardiac Research Laboratory, The Children's Heart Center, Department of Pediatrics, Emory University, Atlanta, Georgia 30322 Action potential conduction through the atrium and the ventricle of the heart depends on the membrane properties of the atrial and ventricular cells, particularly with respect to the determinants of the initiation of action potentials in each cell type. We have utilized both current- and voltage-clamp techniques on isolated cells to examine biophysical properties of the two cell types at physiological temperature. The resting membrane potential, action potential amplitude, current threshold, voltage threshold, and maximum rate of rise measured from atrial cells ( 80 ± 1 mV, 109 ± 3 mV, 0.69 ± 0.05 nA, 59 ± 1 mV, and 206 ± 17 V/s, respectively; means ± SE) differed significantly ( P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.1998.274.6.h1902