Changes in resistance vessels during hemorrhagic shock and resuscitation in conscious hamster model

1  Department of Bioengineering, University of California, San Diego, La Jolla, California, 92093-0412; and 2  Department of Polymer Chemistry, Advanced Research Institute for Science and Engineering, Waseda University, Tokyo 169-8555, Japan The unanesthetized hamster dorsal skinfold preparation was...

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Published in:American journal of physiology. Heart and circulatory physiology 1999-02, Vol.276 (2), p.H563-H571
Main Authors: Sakai, Hiromi, Hara, Hiroyuki, Tsai, Amy G, Tsuchida, Eishun, Johnson, Paul C, Intaglietta, Marcos
Format: Article
Language:English
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Summary:1  Department of Bioengineering, University of California, San Diego, La Jolla, California, 92093-0412; and 2  Department of Polymer Chemistry, Advanced Research Institute for Science and Engineering, Waseda University, Tokyo 169-8555, Japan The unanesthetized hamster dorsal skinfold preparation was used to monitor diameters and blood flow rates in resistance arteries (small arteries, A 0 : diameter, 156 ± 23 µm) and capacitance vessels (small veins, V 0 : 365 ± 64 µm), during 45 min of hemorrhagic shock at 40 mmHg mean arterial pressure (MAP) and resuscitation. A 0 and V 0 vessels constricted significantly to 52 and 70% of the basal values, respectively, whereas precapillary arterioles (A 1 -A 4 , 8-60 µm) and collecting venules (V C -V L , 26-80 µm) did not change or tended to dilate. Blood flow rates in the microvessels declined to
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.1999.276.2.H563