Phospholamban deficiency does not compromise exercise capacity

1  Department of Pediatrics, Stanford University, Stanford, California 94305; and 2  Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio 45267-0575 Deficiency of phospholamban (PLB) results in enhancement of basal murine cardiac function and an attenuated respo...

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Published in:American journal of physiology. Heart and circulatory physiology 1999-04, Vol.276 (4), p.H1172-H1177
Main Authors: Desai, Kavin H, Schauble, Eric, Luo, Wusheng, Kranias, Evangelia, Bernstein, Daniel
Format: Article
Language:English
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Summary:1  Department of Pediatrics, Stanford University, Stanford, California 94305; and 2  Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio 45267-0575 Deficiency of phospholamban (PLB) results in enhancement of basal murine cardiac function and an attenuated response to -adrenergic stimulation. To determine whether the absence of PLB also reduces the reserve capacity of the murine cardiovascular system to respond to stress, we evaluated the heart rate (HR), blood pressure, and metabolic responses of PLB-deficient (PLB / ) mice to graded treadmill exercise (GTE). PLB / mice were hypertensive at rest (125 ± 19   vs. 109 ± 16 mmHg, P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.1999.276.4.h1172