Short-term exercise training can improve myocardial tolerance to I/R without elevation in heat shock proteins

1  Baylor College of Medicine, Cardiology Research, Veterans Affairs Medical Center, Houston, Texas 77030; 2  Department of Exercise and Sport Sciences and Physiology and the Center for Exercise Science, University of Florida, Gainesville, 32611; 3  Geriatric Research, Education and Clinical Center,...

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Published in:American journal of physiology. Heart and circulatory physiology 2001-09, Vol.281 (3), p.H1346-H1352
Main Authors: Hamilton, Karyn L, Powers, Scott K, Sugiura, Takao, Kim, Sunjoo, Lennon, Shannon, Tumer, Nihal, Mehta, Jawahar L
Format: Article
Language:English
Subjects:
Animals
Enzyme Activation
Female
Free Radical Scavengers - metabolism
Heat-Shock Proteins - metabolism
Ischemic Preconditioning, Myocardial - methods
Lipid Peroxidation
Motor Activity
Myocardial Ischemia - physiopathology
Myocardial Reperfusion
Myocardium - metabolism
Physical Conditioning, Animal
Rats
Rats, Sprague-Dawley
Space life sciences
Superoxide Dismutase - metabolism
Temperature
Time Factors
Ventricular Function, Left
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Summary:1  Baylor College of Medicine, Cardiology Research, Veterans Affairs Medical Center, Houston, Texas 77030; 2  Department of Exercise and Sport Sciences and Physiology and the Center for Exercise Science, University of Florida, Gainesville, 32611; 3  Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, and 4  Division of Cardiology, University of Florida College of Medicine, Gainesville, Florida 32610; 5  Department of Exercise and Health Science, Yamaguchi University, Yamaguchi, Japan 753; and 6  Department of Clinical Pathology, Gyeongsang National University School of Medicine, Chinju, Korea 660-702 We examined the effects of 3 days of exercise in a cold environment on the expression of left ventricular (LV) heat shock proteins (HSPs) and contractile performance during in vivo ischemia-reperfusion (I/R). Sprague-Dawley rats were divided into the following three groups ( n  = 12/group): 1 ) control, 2 ) exercise (60 min/day) at 4°C (E-Cold), and 3 ) exercise (60 min/day) at 25°C (E-Warm). Left anterior descending coronary occlusion was maintained for 20 min, followed by 30 min of reperfusion. Compared with the control group, both the E-Cold and E-Warm groups maintained higher ( P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.2001.281.3.h1346