Liposomal VIP attenuates phenylephrine- and ANG II-induced vasoconstriction in vivo

Departments of Medicine and Pharmaceutics and Pharmacodynamics, University of Illinois at Chicago, and West Side Department of Veterans Affairs Medical Center, Chicago, Illinois 60612 The purpose of this study was to determine whether vasoactive intestinal peptide (VIP) modulates vasoconstriction el...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-08, Vol.275 (2), p.588-R595
Main Authors: Ikezaki, Hiroyuki, Onyuksel, Hayat, Rubinstein, Israel
Format: Article
Language:English
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Summary:Departments of Medicine and Pharmaceutics and Pharmacodynamics, University of Illinois at Chicago, and West Side Department of Veterans Affairs Medical Center, Chicago, Illinois 60612 The purpose of this study was to determine whether vasoactive intestinal peptide (VIP) modulates vasoconstriction elicited by phenylephrine and ANG II in vivo and, if so, to begin to elucidate the mechanisms underlying this phenomenon. Using intravital microscopy, we found that suffusion of phenylephrine and ANG II elicits significant vasoconstriction in the in situ hamster cheek pouch that is potentiated by VIP-(10 28), a VIP receptor antagonist, but not by VIP-(1 12) ( P  
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.1998.275.2.r588