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Increased cerebral infarction by cyclic flow reductions: studies in the guinea pig MCA thrombosis model
Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan We have developed a photochemical model of thrombotic middle cerebral artery (MCA) occlusion in the guinea pig for investigating factors contributing to the development of cerebral infarction. In this mode...
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Published in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-11, Vol.275 (5), p.1578-R1583 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Department of Pharmacology, Hamamatsu University School of
Medicine, Hamamatsu 431-3192, Japan
We have developed a photochemical model
of thrombotic middle cerebral artery (MCA) occlusion in the guinea pig
for investigating factors contributing to the development of cerebral
infarction. In this model, cyclic flow reductions (CFRs) after
recanalization of the MCA are a common observation and might contribute
to the development of cerebral infarction. Therefore, we sought to
measure the time course of recanalization of the guinea pig MCA after the artery had been occluded by a thrombus. Thrombotic occlusion of the
MCA was induced by photochemical reaction between intravenously administered rose bengal and transluminal green light for 10, 15, 20, or 30 min. After the thrombotic occlusion of MCA and subsequent spontaneous thrombolysis, blood flow in the MCA gradually recovered to
preocclusion level but with frequent CFRs. The recovery of MCA blood
flow or duration of CFRs was dependent on the duration of photochemical
reaction (extent of endothelial injury); thus, for a 30-min
photochemical reaction, CFRs were still observed 24 h after
photochemical reaction. In separate experiments, we also investigated
the effect of permanent occlusion of the MCA, which was induced by
electrocoagulation in the vessel on cerebral infarction. The infarct
volume in the permanent occlusion model was smaller than the maximum
value in the thrombotic occlusion model (12.5 vs. 17.4%;
P |
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ISSN: | 0363-6119 1522-1490 |
DOI: | 10.1152/ajpregu.1998.275.5.r1578 |