Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function

Departments of Medicine and Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905 The purpose of the present investigation was to study the effects of inhibition of monoamine oxidase (MAO) and/or catechol- O -methyltransferase (COMT), enzymes involved in the degradat...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-01, Vol.280 (1), p.248-R254
Main Authors: Wang, Yongqing, Berndt, Theresa J, Gross, Jennifer M, Peterson, Michael A, So, Mathew J, Knox, Franklyn G
Format: Article
Language:English
Subjects:
Animals
Catechol O-Methyltransferase - metabolism
Catechol O-Methyltransferase Inhibitors
Dopamine - analysis
Dopamine - urine
Enzyme Inhibitors - pharmacology
Extracellular Space - chemistry
Extracellular Space - metabolism
Glomerular Filtration Rate - drug effects
Glomerular Filtration Rate - physiology
Kidney - enzymology
Male
Microdialysis
Monoamine Oxidase - metabolism
Monoamine Oxidase Inhibitors - pharmacology
Phosphates - metabolism
Rats
Serotonin - analysis
Serotonin - urine
Sodium - metabolism
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Summary:Departments of Medicine and Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905 The purpose of the present investigation was to study the effects of inhibition of monoamine oxidase (MAO) and/or catechol- O -methyltransferase (COMT), enzymes involved in the degradation of dopamine (DA) and serotonin (5-HT), on intrarenal DA and 5-HT, as reflected in the renal interstitial fluid (RIF) microdialysate and urine, and on renal function. Inhibition of MAO selectively increased RIF 5-HT from 3.16 ± 0.38 to 8.03 ± 1.83 pg/min ( n  = 7,  P  
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.2001.280.1.R248