Differential effects of an NMDA and a non-NMDA receptor antagonist on medullary lateral tegmental field neurons

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2002-01, Vol.282 (1), p.100-R113
• Main Authors: Barman, Susan M, Orer, Hakan S, Gebber, Gerard L
• Format: Article
• Language: English
• Subjects: 2-Amino-5-phosphonovalerate - pharmacology; Animals; Cats; Excitatory Amino Acid Antagonists - pharmacology; Heart Rate - physiology; Iontophoresis; Medulla Oblongata - cytology; Medulla Oblongata - physiology; Neurons - drug effects; Neurons - physiology; Pressoreceptors - physiology; Quinoxalines - pharmacology; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - physiology; Sympathetic Nervous System - cytology; Sympathetic Nervous System - physiology; Tegmentum Mesencephali - cytology; Tegmentum Mesencephali - physiology
• ISSN: 0363-6119; 1522-1490
• DOI: 10.1152/ajpregu.2002.282.1.r100

1  Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824; and 2  Department of Pharmacology, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey We microiontophoresed an N -methyl- D -aspartate (NMDA) and a non-NMDA receptor antagonist onto medullary lateral tegmental field (LTF) neurons, the naturally occurring discharges of which were correlated to the cardiac-related rhythm in sympathetic nerve discharge (SND) of dialurethane-anesthetized cats. Some of these neurons were classified as sympathoexcitatory, because their firing rate decreased during baroreceptor reflex activation. Microiontophoresis of 1,2,3,4-tetrahydro-6-nitro-2,3-dioxobenzo-[ f ]quinoxaline-7-sulfonamide (NBQX), a non-NMDA receptor antagonist, reduced the mean firing rates of these neurons (51 ± 8% of control, P