Effects of a training program on resting plasma 2-hydroxycatecholestrogen levels in eumenorrheic women

• Published in: Journal of applied physiology (1985) 1997-11, Vol.83 (5), p.1551-1556
• Main Authors: De Cree, Carl, Ball, Peter, Seidlitz, Barbel, Van Kranenburg, Gerrit, Geurten, Peter, Keizer, Hans A
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Catechol O-Methyltransferase - metabolism; Catecholamines - blood; Estrogens - blood; Estrogens, Catechol - blood; Female; Fundamental and applied biological sciences. Psychology; Hormone metabolism and regulation; Hormones - blood; Humans; Male; Mammalian female genital system; Menstrual Cycle - physiology; Oxygen Consumption - physiology; Physical Fitness - physiology; Vertebrates: reproduction
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1997.83.5.1551

Carl De Crée 1 , Peter Ball 2 , Bärbel Seidlitz 2 , Gerrit Van Kranenburg 3 , Peter Geurten 3 , and Hans A. Keizer 3 Interuniversity Project on Reproductive Endocrinology in Women and Exercise, 1  Department of Applied and Experimental Reproductive Endocrinology, B-3000 Leuven 3, Belgium; 2  Department of Biochemical and Clinical Endocrinology, Medical University of Lübeck, D-23538 Lübeck, Germany; and 3  Department of Movement Sciences, Faculty of Health Sciences, University of Maastricht, NL-6200 MD Maastricht, The Netherlands Received 11 February 1997; accepted in final form 16 June 1997. De Crée, Carl, Peter Ball, Bärbel Seidlitz, Gerrit Van Kranenburg, Peter Geurten, and Hans A. Keizer. Effects of a training program on resting plasma 2-hydroxycatecholestrogen levels in eumenorrheic women. J. Appl. Physiol. 83(5): 1551-1556, 1997. Catecholestrogens (CE) represent a major metabolic pathway in estrogen metabolism. Previous information on CE and training is limited to two cross-sectional studies that did not involve standardized training. Our purpose, by means of a prospective design, was to evaluate the effects of a brief, exhaustive training program on resting plasma concentrations of 2-hydroxy CE. The experimental design spanned two menstrual cycles: a control cycle and a training cycle. The subjects were nine previously untrained, eumenorrheic women [body fat: 24.8 ± 1.0 (SE) %]. Data were collected during the follicular (FPh) and the luteal phases (LPh). Posttraining FPh and LPh tests were held the day after the last day of a 5-day period of training on a cycle ergometer. Total 2-hydroxyestrogens (2-OHE) averaged 200 ± 29 pg/ml during the FPh and 420 ± 54 pg/ml during the LPh ( P