Effect of neuropeptide Y on hemodynamics of the rabbit lung

• Published in: Journal of applied physiology (1985) 1998-02, Vol.84 (2), p.618-623
• Main Authors: Lang, Sally A, Maron, Michael B
• Format: Article
• Language: English
• Subjects: Air breathing; Animals; Biological and medical sciences; Cisterna Magna; Fundamental and applied biological sciences. Psychology; Hemodynamics - physiology; In Vitro Techniques; Injections; Neuropeptide Y - blood; Neuropeptide Y - pharmacology; Neuropeptide Y - physiology; Norepinephrine - pharmacology; Perfusion; Pulmonary Circulation - drug effects; Pulmonary Circulation - physiology; Rabbits; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - physiology; Vascular Resistance - drug effects; Vascular Resistance - physiology; Vasoconstriction - drug effects; Vasoconstriction - physiology; Vasoconstrictor Agents - pharmacology; Veratrine - administration & dosage; Veratrine - pharmacology; Vertebrates: respiratory system
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1998.84.2.618

Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 Lang, Sally A., and Michael B. Maron. Effect of neuropeptide Y on hemodynamics of the rabbit lung. J. Appl. Physiol. 84(2): 618-623, 1998. We evaluated the effect of neuropeptide Y (NPY) on the hemodynamics of the isolated rabbit lung perfused at constant flow and outflow pressure. Doses of 10 8 and 10 7 M NPY increased pulmonary arterial pressure (Ppa) from 11.5 ± 1.0 (SE) mmHg to, respectively, 16.4 ± 1.5 and 26.0 ± 3.8 mmHg ( P