Glucose uptake and metabolic stress in rat muscles stimulated electrically with different protocols

1  Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N-0317 Oslo; 2  The Norwegian University of Sport and Physical Education, N-0806 Oslo; 3  Department of Physiology, National Institute of Occupational Health, N-0033 Oslo, Norway; and 4  Institute of Sport Science and...

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Published in:Journal of applied physiology (1985) 2001-09, Vol.91 (3), p.1237-1244
Main Authors: Aslesen, Rune, Engebretsen, Ellen M. L, Franch, Jesper, Jensen, Jorgen
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Biological and medical sciences
Electric Stimulation
Energy Metabolism - physiology
Fatigue
Fundamental and applied biological sciences. Psychology
Glucose
Glucose - pharmacokinetics
Glycogen - metabolism
In Vitro Techniques
Male
Metabolism
Muscle Contraction - physiology
Muscle Fatigue - physiology
Muscle Fibers, Fast-Twitch - metabolism
Muscle Fibers, Slow-Twitch - metabolism
Muscle, Skeletal - cytology
Muscle, Skeletal - metabolism
Muscular system
Phosphocreatine - metabolism
Rats
Rats, Wistar
Rodents
Stress, Physiological - metabolism
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:1  Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N-0317 Oslo; 2  The Norwegian University of Sport and Physical Education, N-0806 Oslo; 3  Department of Physiology, National Institute of Occupational Health, N-0033 Oslo, Norway; and 4  Institute of Sport Science and Physical Education, Odense University, DK-5230 Odense, Denmark In the present study, the relationship between the pattern of electrical stimulation and glucose uptake was investigated in slow-twitch muscles (soleus) and fast-twitch muscles (epitrochlearis) from Wistar rats. Muscles were stimulated electrically for 30   min in vitro with either single pulses (frequencies varied between 0.8 and 15 Hz) or with 200-ms trains (0.1-2 Hz). Glucose uptake (measured with tracer amount of 2-[ 3 H]deoxyglucose) increased with increasing number of impulses whether delivered as single pulses or as short trains. The highest glucose uptake achieved with short tetanic contractions was similar in soleus and epitrochlearis (10.9 ± 0.7 and 12.0 ± 0.8 mmol · kg dry wt 1 · 30 min 1 , respectively). Single pulses, on the other hand, increased contraction-stimulated glucose uptake less in soleus than in epitrochlearis (7.5 ± 1.1   and 11.7 ± 0.5 mmol · kg dry wt 1 · 30 min 1 , respectively; P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.2001.91.3.1237