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Invited Review: Aging and the cardiovascular system
Dipartimento di Medicina, Prevenzione e Biotecnologie Sanitarie, Centro di Fisiologia Clinica e Ipertensione, Università di Milano-Bicocca, 20122 Milano; Divisione di Cardioriabilitazione, Ospedale di Seregno, Azienda Ospedaliera Vimercate (MI), 20059 Vimercate, Italy Aging is associated with comple...
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| Published in: | Journal of applied physiology (1985) 2003-12, Vol.95 (6), p.2591-2597 |
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| Main Authors: | , , |
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| cited_by | cdi_FETCH-LOGICAL-c412t-602e09bce07a459f59953185763a372ca7c02f68a2252596dc83a6c460446bb53 |
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| cites | cdi_FETCH-LOGICAL-c412t-602e09bce07a459f59953185763a372ca7c02f68a2252596dc83a6c460446bb53 |
| container_end_page | 2597 |
| container_issue | 6 |
| container_start_page | 2591 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 95 |
| creator | Ferrari, Alberto U Radaelli, Alberto Centola, Marco |
| description | Dipartimento di Medicina, Prevenzione e Biotecnologie Sanitarie, Centro di Fisiologia Clinica e Ipertensione, Università di Milano-Bicocca, 20122 Milano; Divisione di Cardioriabilitazione, Ospedale di Seregno, Azienda Ospedaliera Vimercate (MI), 20059 Vimercate, Italy
Aging is associated with complex and diversified changes of cardiovascular structure and function. The heart becomes slightly hypertrophic and hyporesponsive to sympathetic (but not parasympathetic) stimuli, so that the exercise-induced increases in heart rate and myocardial contractility are blunted in older hearts. The aorta and major elastic arteries become elongated and stiffer, with increased pulse wave velocity, evidence of endothelial dysfunction, and biochemical patterns resembling early atherosclerosis. The arterial baroreflex is sizably altered in aging, but different components are differentially affected: there is a definite impairment of arterial baroreceptor control of the heart but much better preserved baroreceptor control of peripheral vascular resistance. Alterations at the afferent, central neural, efferent, and effector organ portions of the reflex arch have been claimed to account for age-related baroreflex changes, but no conclusive evidence is available on this mechanistic aspect. Reflexes arising from cardiopulmonary vagal afferents are also blunted in aged individuals. The cardiovascular and reflex changes brought about by aging may have significant implications for circulatory homeostasis in health and disease.
heart; blood vessels; atherosclerosis; baroreceptor reflexes; autonomic nervous system
Address for reprint requests and other correspondence: A. U. Ferrari, Centro Fisiologia Clinica e Ipertensione, Via F. Sforza, 35, 20122 Milano (E-mail: alberto.ferrari{at}unimib.it ). |
| doi_str_mv | 10.1152/japplphysiol.00601.2003 |
| format | article |
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Aging is associated with complex and diversified changes of cardiovascular structure and function. The heart becomes slightly hypertrophic and hyporesponsive to sympathetic (but not parasympathetic) stimuli, so that the exercise-induced increases in heart rate and myocardial contractility are blunted in older hearts. The aorta and major elastic arteries become elongated and stiffer, with increased pulse wave velocity, evidence of endothelial dysfunction, and biochemical patterns resembling early atherosclerosis. The arterial baroreflex is sizably altered in aging, but different components are differentially affected: there is a definite impairment of arterial baroreceptor control of the heart but much better preserved baroreceptor control of peripheral vascular resistance. Alterations at the afferent, central neural, efferent, and effector organ portions of the reflex arch have been claimed to account for age-related baroreflex changes, but no conclusive evidence is available on this mechanistic aspect. Reflexes arising from cardiopulmonary vagal afferents are also blunted in aged individuals. The cardiovascular and reflex changes brought about by aging may have significant implications for circulatory homeostasis in health and disease.
heart; blood vessels; atherosclerosis; baroreceptor reflexes; autonomic nervous system
Address for reprint requests and other correspondence: A. U. Ferrari, Centro Fisiologia Clinica e Ipertensione, Via F. Sforza, 35, 20122 Milano (E-mail: alberto.ferrari{at}unimib.it ).</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00601.2003</identifier><identifier>PMID: 14600164</identifier><language>eng</language><publisher>United States: Am Physiological Soc</publisher><subject>Aging ; Aging - physiology ; Baroreflex - physiology ; Blood Vessels - growth & development ; Blood Vessels - physiology ; Cardiology ; Cardiovascular System - growth & development ; Circulatory system ; Coronary vessels ; Exercise ; Heart ; Heart - growth & development ; Heart - physiology ; Homeostasis - physiology ; Humans ; Reflexes</subject><ispartof>Journal of applied physiology (1985), 2003-12, Vol.95 (6), p.2591-2597</ispartof><rights>Copyright American Physiological Society Dec 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-602e09bce07a459f59953185763a372ca7c02f68a2252596dc83a6c460446bb53</citedby><cites>FETCH-LOGICAL-c412t-602e09bce07a459f59953185763a372ca7c02f68a2252596dc83a6c460446bb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14600164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrari, Alberto U</creatorcontrib><creatorcontrib>Radaelli, Alberto</creatorcontrib><creatorcontrib>Centola, Marco</creatorcontrib><title>Invited Review: Aging and the cardiovascular system</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Dipartimento di Medicina, Prevenzione e Biotecnologie Sanitarie, Centro di Fisiologia Clinica e Ipertensione, Università di Milano-Bicocca, 20122 Milano; Divisione di Cardioriabilitazione, Ospedale di Seregno, Azienda Ospedaliera Vimercate (MI), 20059 Vimercate, Italy
Aging is associated with complex and diversified changes of cardiovascular structure and function. The heart becomes slightly hypertrophic and hyporesponsive to sympathetic (but not parasympathetic) stimuli, so that the exercise-induced increases in heart rate and myocardial contractility are blunted in older hearts. The aorta and major elastic arteries become elongated and stiffer, with increased pulse wave velocity, evidence of endothelial dysfunction, and biochemical patterns resembling early atherosclerosis. The arterial baroreflex is sizably altered in aging, but different components are differentially affected: there is a definite impairment of arterial baroreceptor control of the heart but much better preserved baroreceptor control of peripheral vascular resistance. Alterations at the afferent, central neural, efferent, and effector organ portions of the reflex arch have been claimed to account for age-related baroreflex changes, but no conclusive evidence is available on this mechanistic aspect. Reflexes arising from cardiopulmonary vagal afferents are also blunted in aged individuals. The cardiovascular and reflex changes brought about by aging may have significant implications for circulatory homeostasis in health and disease.
heart; blood vessels; atherosclerosis; baroreceptor reflexes; autonomic nervous system
Address for reprint requests and other correspondence: A. U. Ferrari, Centro Fisiologia Clinica e Ipertensione, Via F. Sforza, 35, 20122 Milano (E-mail: alberto.ferrari{at}unimib.it ).</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Baroreflex - physiology</subject><subject>Blood Vessels - growth & development</subject><subject>Blood Vessels - physiology</subject><subject>Cardiology</subject><subject>Cardiovascular System - growth & development</subject><subject>Circulatory system</subject><subject>Coronary vessels</subject><subject>Exercise</subject><subject>Heart</subject><subject>Heart - growth & development</subject><subject>Heart - physiology</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Reflexes</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp1kFtLwzAYhoMobh7-ghYvxJvOnJN6N8QTDATR65Cl6ZbRtTVpN_vvzdxQEbwKSZ735fseAM4RHCHE8PVCN03ZzPvg6nIEIYdohCEke2AYf3GK4sM-GErBYCqYFANwFMICQkQpQ4dggCiPF06HgDxVK9faPHmxK2fXN8l45qpZoqs8aec2Mdrnrl7pYLpS-yT0obXLE3BQ6DLY0915DN7u715vH9PJ88PT7XiSGopwm3KILcymxkKhKcsKlmWMIMkEJ5oIbLQwEBdcaowZZhnPjSSamzgapXw6ZeQYXG57G1-_dza0aumCsWWpK1t3QQlEqJSIRPDiD7ioO1_F2RTGGAmJhYyQ2ELG1yF4W6jGu6X2vUJQbaSq31LVl1S1kRqTZ7v6brq0-U9uZzECdAvM3Wy-dt6qXUs969V9V5av9qPd1GdMcRV3RarJixi7-j8WafWNk0_6ypVs</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Ferrari, Alberto U</creator><creator>Radaelli, Alberto</creator><creator>Centola, Marco</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Invited Review: Aging and the cardiovascular system</title><author>Ferrari, Alberto U ; Radaelli, Alberto ; Centola, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-602e09bce07a459f59953185763a372ca7c02f68a2252596dc83a6c460446bb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aging</topic><topic>Aging - physiology</topic><topic>Baroreflex - physiology</topic><topic>Blood Vessels - growth & development</topic><topic>Blood Vessels - physiology</topic><topic>Cardiology</topic><topic>Cardiovascular System - growth & development</topic><topic>Circulatory system</topic><topic>Coronary vessels</topic><topic>Exercise</topic><topic>Heart</topic><topic>Heart - growth & development</topic><topic>Heart - physiology</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Reflexes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrari, Alberto U</creatorcontrib><creatorcontrib>Radaelli, Alberto</creatorcontrib><creatorcontrib>Centola, Marco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrari, Alberto U</au><au>Radaelli, Alberto</au><au>Centola, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Invited Review: Aging and the cardiovascular system</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>95</volume><issue>6</issue><spage>2591</spage><epage>2597</epage><pages>2591-2597</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>Dipartimento di Medicina, Prevenzione e Biotecnologie Sanitarie, Centro di Fisiologia Clinica e Ipertensione, Università di Milano-Bicocca, 20122 Milano; Divisione di Cardioriabilitazione, Ospedale di Seregno, Azienda Ospedaliera Vimercate (MI), 20059 Vimercate, Italy
Aging is associated with complex and diversified changes of cardiovascular structure and function. The heart becomes slightly hypertrophic and hyporesponsive to sympathetic (but not parasympathetic) stimuli, so that the exercise-induced increases in heart rate and myocardial contractility are blunted in older hearts. The aorta and major elastic arteries become elongated and stiffer, with increased pulse wave velocity, evidence of endothelial dysfunction, and biochemical patterns resembling early atherosclerosis. The arterial baroreflex is sizably altered in aging, but different components are differentially affected: there is a definite impairment of arterial baroreceptor control of the heart but much better preserved baroreceptor control of peripheral vascular resistance. Alterations at the afferent, central neural, efferent, and effector organ portions of the reflex arch have been claimed to account for age-related baroreflex changes, but no conclusive evidence is available on this mechanistic aspect. Reflexes arising from cardiopulmonary vagal afferents are also blunted in aged individuals. The cardiovascular and reflex changes brought about by aging may have significant implications for circulatory homeostasis in health and disease.
heart; blood vessels; atherosclerosis; baroreceptor reflexes; autonomic nervous system
Address for reprint requests and other correspondence: A. U. Ferrari, Centro Fisiologia Clinica e Ipertensione, Via F. Sforza, 35, 20122 Milano (E-mail: alberto.ferrari{at}unimib.it ).</abstract><cop>United States</cop><pub>Am Physiological Soc</pub><pmid>14600164</pmid><doi>10.1152/japplphysiol.00601.2003</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of applied physiology (1985), 2003-12, Vol.95 (6), p.2591-2597 |
| issn | 8750-7587 1522-1601 |
| language | eng |
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| source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
| subjects | Aging Aging - physiology Baroreflex - physiology Blood Vessels - growth & development Blood Vessels - physiology Cardiology Cardiovascular System - growth & development Circulatory system Coronary vessels Exercise Heart Heart - growth & development Heart - physiology Homeostasis - physiology Humans Reflexes |
| title | Invited Review: Aging and the cardiovascular system |
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