Blood extraction from lancet wounds using vacuum combined with skin stretching

1  Abbott Laboratories, Abbott Park 60064-6015; and 2  Department of Surgery, The University of Chicago Hospitals, Chicago, Illinois 60637 Key factors and practical limits of blood extraction from lancet wounds on body sites other than the finger were determined by testing a large number of conditio...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2002-03, Vol.92 (3), p.1089-1096
Main Authors: Cunningham, David D, Henning, Timothy P, Shain, Eric B, Young, Douglas F, Hannig, Jurgen, Barua, Eric, Lee, Raphael C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood
Blood Specimen Collection - adverse effects
Blood Specimen Collection - instrumentation
Blood Specimen Collection - methods
Diabetes
Diabetes. Impaired glucose tolerance
Diagnostic tests
Elasticity
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Equipment and Supplies
Equipment Design
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glucose
Hot Temperature
Humans
Laser-Doppler Flowmetry
Medical sciences
Pain - etiology
Pulsatile Flow
Regional Blood Flow
Skin - blood supply
Skin Physiological Phenomena
Stress, Mechanical
Time Factors
Vacuum
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Summary:1  Abbott Laboratories, Abbott Park 60064-6015; and 2  Department of Surgery, The University of Chicago Hospitals, Chicago, Illinois 60637 Key factors and practical limits of blood extraction from lancet wounds on body sites other than the finger were determined by testing a large number of conditions. During these tests, the pain associated with lancing alternate body sites was rated as less painful than a fingerstick 98% of the time. Vacuum combined with skin stretching was effective in extracting an adequate volume of blood from the forearm for glucose testing, up to an average of 16 µl in 30 s. The amount of blood extracted increases with the application of heat or vacuum before lancing, the level of vacuum, the depth of lancing, the time of collection, and the amount of skin stretching. Vacuum and skin stretching led to significant increases, up to fivefold in the perfusion of blood in the skin as measured by laser Doppler. Our observations suggest that vacuum combined with skin stretching increases blood extraction at alternate sites by increasing the lancet wound opening, increasing the blood available for extraction by vasodilatation, and reducing the venous return of blood through capillaries. suction; diabetes; diagnostics; alternate site; glucose measurement
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00798.2001