Selective Depolarization of Interneurons in the Early Posttraumatic Dentate Gyrus: Involvement of the Na+/K+-ATPase

Department of Anatomy and Neurobiology, University of California, Irvine, California 92697-1280 Ross, Stephen T. and Ivan Soltesz. Selective Depolarization of Interneurons in the Early Posttraumatic Dentate Gyrus: Involvement of the Na + /K + -ATPase. J. Neurophysiol. 83: 2916-2930, 2000. Interneuro...

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Published in:Journal of neurophysiology 2000-05, Vol.83 (5), p.2916-2930
Main Authors: Ross, Stephen T, Soltesz, Ivan
Format: Article
Language:English
Subjects:
2-Amino-5-phosphonovalerate - pharmacology
6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology
Action Potentials
Animals
Benzoates - pharmacology
Bicuculline - pharmacology
Brain Injuries - enzymology
Dentate Gyrus - cytology
Dentate Gyrus - drug effects
Dentate Gyrus - enzymology
Dentate Gyrus - injuries
Electric Stimulation
Excitatory Amino Acid Antagonists - pharmacology
Excitatory Postsynaptic Potentials
GABA Antagonists - pharmacology
Glycine - analogs & derivatives
Glycine - pharmacology
In Vitro Techniques
Interneurons - cytology
Interneurons - drug effects
Interneurons - enzymology
Membrane Potentials
Patch-Clamp Techniques
Pyrimidines - pharmacology
Rats
Rats, Wistar
Sodium-Potassium-Exchanging ATPase - metabolism
Strophanthidin - pharmacology
Tetrodotoxin - pharmacology
Wounds, Nonpenetrating - metabolism
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Summary:Department of Anatomy and Neurobiology, University of California, Irvine, California 92697-1280 Ross, Stephen T. and Ivan Soltesz. Selective Depolarization of Interneurons in the Early Posttraumatic Dentate Gyrus: Involvement of the Na + /K + -ATPase. J. Neurophysiol. 83: 2916-2930, 2000. Interneurons innervating dentate granule cells are potent regulators of the entorhino-hippocampal interplay. Traumatic brain injury, a leading cause of death and disability among young adults, is frequently associated with rapid neuropathological changes, seizures, and short-term memory deficits both in humans and experimental animals, indicating significant posttraumatic perturbations of hippocampal circuits. To determine the pathophysiological alterations that affect the posttraumatic functions of dentate neuronal networks within the important early (hours to days) posttraumatic period, whole cell patch-clamp recordings were performed from granule cells and interneurons situated in the granule cell layer of the dentate gyrus of head-injured and age-matched, sham-operated control rats. The data show that a single pressure wave-transient delivered to the neocortex of rats (mimicking moderate concussive head trauma) resulted in a characteristic (~10 mV), transient (
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.2000.83.5.2916