Topography of EEG Dynamics After Sleep Deprivation in Mice

• Published in: Journal of neurophysiology 2000-10, Vol.84 (4), p.1888-1893
• Main Authors: Huber, Reto, Deboer, Tom, Tobler, Irene
• Format: Article
• Language: English
• Subjects: Animals; Electroencephalography; Frontal Lobe - physiopathology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Occipital Lobe - physiopathology; Sleep Deprivation - physiopathology; Sleep Stages - physiology
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.2000.84.4.1888

Institute of Pharmacology and Toxicology, University of Zürich, CH-8057 Zurich, Switzerland Huber, Reto, Tom Deboer, and Irene Tobler. Topography of EEG Dynamics After Sleep Deprivation in Mice. J. Neurophysiol. 84: 1888-1893, 2000. Several recent results show that sleep and sleep regulation are not only global phenomena encompassing the entire brain, but have local features. It is well established that slow-wave activity [SWA; mean electroencephalographic (EEG) power density in the 0.75-4.0 Hz band] in non-rapid eye movement (NREM) sleep is a function of the prior history of sleep and wakefulness. SWA is thought to reflect the homeostatic component of the two-process model of sleep regulation. According to this model, originally formulated for the rat and later extended to human sleep, the timing and structure of sleep are determined by the interaction of a homeostatic Process S and a circadian process. Our aim was to investigate the dynamics of SWA in the EEG of two brain regions (frontal and occipital cortex) after sleep deprivation (SD) in two of the mice strains most often used in gene targeting. C57BL/6J ( n  = 9) and 129/Ola ( n  = 8) were recorded during a 24-h baseline day, 6-h SD, and 18-h recovery. Both derivations showed a significant increase in SWA in NREM sleep after SD in both strains. In the first hour of recovery, SWA was enhanced more in the frontal derivation than in the occipital derivation and showed a faster decline. This difference resulted in a lower value for the time constant for the decrease of SWA in the frontal derivation (frontal: 10.9   ± 2.1 and 6.8 ± 0.9 h in Ola and C57, respectively; occipital: 16.6 ± 2.1 and 14.1 ± 1.5 h; P