Gasotransmitter Regulation of Ion Channels: A Key Step in O 2 Sensing By the Carotid Body

Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O 2 sensing by the carotid bod...

Full description

Saved in:
Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2014-01, Vol.29 (1), p.49-57
Main Authors: Prabhakar, Nanduri R., Peers, Chris
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c177t-b1c20a542edf06e5f70dfe4f7924184436589d2d6a57442eb2d1281b322997bd3
cites cdi_FETCH-LOGICAL-c177t-b1c20a542edf06e5f70dfe4f7924184436589d2d6a57442eb2d1281b322997bd3
container_end_page 57
container_issue 1
container_start_page 49
container_title Physiology (Bethesda, Md.)
container_volume 29
creator Prabhakar, Nanduri R.
Peers, Chris
description Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O 2 sensing by the carotid body. Here, we review current understanding of hypoxia-dependent production of gasotransmitters, how they regulate ion channels in the carotid body, and how this impacts carotid body function.
doi_str_mv 10.1152/physiol.00034.2013
format article
fullrecord <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_1152_physiol_00034_2013</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1152_physiol_00034_2013</sourcerecordid><originalsourceid>FETCH-LOGICAL-c177t-b1c20a542edf06e5f70dfe4f7924184436589d2d6a57442eb2d1281b322997bd3</originalsourceid><addsrcrecordid>eNo9kLFOwzAURS0EEqXwA0zvB1LsZ7tJ2NoISkWlShQGpsip7TYotSvbDPl7UqiYzh2O7nAIuWd0wpjEh-O-j63vJpRSLiZIGb8gIyZFkZWI7PJ_M35NbmL8GjRZSByRz4WKPgXl4qFNyQR4M7vvTqXWO_AWlgOqvXLOdPERZvBqetgkc4TWwRoQNsbF1u1g3kPaG6hU8KnVMPe6vyVXVnXR3J05Jh_PT-_VS7ZaL5bVbJVtWZ6nrGFbpEoKNNrSqZE2p9oaYfMSBSuE4FNZlBr1VMlcDFaDmmHBGo5Ylnmj-Zjg3-82-BiDsfUxtAcV-prR-hSnPsepf-PUpzj8B7_HWIg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Gasotransmitter Regulation of Ion Channels: A Key Step in O 2 Sensing By the Carotid Body</title><source>American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish &amp; Join’ Agreement:2023-2024 (Reading list)</source><source>American Physiological Society Free</source><creator>Prabhakar, Nanduri R. ; Peers, Chris</creator><creatorcontrib>Prabhakar, Nanduri R. ; Peers, Chris</creatorcontrib><description>Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O 2 sensing by the carotid body. Here, we review current understanding of hypoxia-dependent production of gasotransmitters, how they regulate ion channels in the carotid body, and how this impacts carotid body function.</description><identifier>ISSN: 1548-9213</identifier><identifier>EISSN: 1548-9221</identifier><identifier>DOI: 10.1152/physiol.00034.2013</identifier><language>eng</language><ispartof>Physiology (Bethesda, Md.), 2014-01, Vol.29 (1), p.49-57</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c177t-b1c20a542edf06e5f70dfe4f7924184436589d2d6a57442eb2d1281b322997bd3</citedby><cites>FETCH-LOGICAL-c177t-b1c20a542edf06e5f70dfe4f7924184436589d2d6a57442eb2d1281b322997bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Prabhakar, Nanduri R.</creatorcontrib><creatorcontrib>Peers, Chris</creatorcontrib><title>Gasotransmitter Regulation of Ion Channels: A Key Step in O 2 Sensing By the Carotid Body</title><title>Physiology (Bethesda, Md.)</title><description>Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O 2 sensing by the carotid body. Here, we review current understanding of hypoxia-dependent production of gasotransmitters, how they regulate ion channels in the carotid body, and how this impacts carotid body function.</description><issn>1548-9213</issn><issn>1548-9221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNo9kLFOwzAURS0EEqXwA0zvB1LsZ7tJ2NoISkWlShQGpsip7TYotSvbDPl7UqiYzh2O7nAIuWd0wpjEh-O-j63vJpRSLiZIGb8gIyZFkZWI7PJ_M35NbmL8GjRZSByRz4WKPgXl4qFNyQR4M7vvTqXWO_AWlgOqvXLOdPERZvBqetgkc4TWwRoQNsbF1u1g3kPaG6hU8KnVMPe6vyVXVnXR3J05Jh_PT-_VS7ZaL5bVbJVtWZ6nrGFbpEoKNNrSqZE2p9oaYfMSBSuE4FNZlBr1VMlcDFaDmmHBGo5Ylnmj-Zjg3-82-BiDsfUxtAcV-prR-hSnPsepf-PUpzj8B7_HWIg</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Prabhakar, Nanduri R.</creator><creator>Peers, Chris</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201401</creationdate><title>Gasotransmitter Regulation of Ion Channels: A Key Step in O 2 Sensing By the Carotid Body</title><author>Prabhakar, Nanduri R. ; Peers, Chris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c177t-b1c20a542edf06e5f70dfe4f7924184436589d2d6a57442eb2d1281b322997bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prabhakar, Nanduri R.</creatorcontrib><creatorcontrib>Peers, Chris</creatorcontrib><collection>CrossRef</collection><jtitle>Physiology (Bethesda, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prabhakar, Nanduri R.</au><au>Peers, Chris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gasotransmitter Regulation of Ion Channels: A Key Step in O 2 Sensing By the Carotid Body</atitle><jtitle>Physiology (Bethesda, Md.)</jtitle><date>2014-01</date><risdate>2014</risdate><volume>29</volume><issue>1</issue><spage>49</spage><epage>57</epage><pages>49-57</pages><issn>1548-9213</issn><eissn>1548-9221</eissn><abstract>Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O 2 sensing by the carotid body. Here, we review current understanding of hypoxia-dependent production of gasotransmitters, how they regulate ion channels in the carotid body, and how this impacts carotid body function.</abstract><doi>10.1152/physiol.00034.2013</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1548-9213
ispartof Physiology (Bethesda, Md.), 2014-01, Vol.29 (1), p.49-57
issn 1548-9213
1548-9221
language eng
recordid cdi_crossref_primary_10_1152_physiol_00034_2013
source American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free
title Gasotransmitter Regulation of Ion Channels: A Key Step in O 2 Sensing By the Carotid Body
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T09%3A02%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gasotransmitter%20Regulation%20of%20Ion%20Channels:%20A%20Key%20Step%20in%20O%202%20Sensing%20By%20the%20Carotid%20Body&rft.jtitle=Physiology%20(Bethesda,%20Md.)&rft.au=Prabhakar,%20Nanduri%20R.&rft.date=2014-01&rft.volume=29&rft.issue=1&rft.spage=49&rft.epage=57&rft.pages=49-57&rft.issn=1548-9213&rft.eissn=1548-9221&rft_id=info:doi/10.1152/physiol.00034.2013&rft_dat=%3Ccrossref%3E10_1152_physiol_00034_2013%3C/crossref%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c177t-b1c20a542edf06e5f70dfe4f7924184436589d2d6a57442eb2d1281b322997bd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true