Does cardio-hepatic communication contribute to pregnancy-induced cardiac growth and its reversal?

Abstract only Introduction: During pregnancy, the maternal heart undergoes physiological cardiac growth, which reverses following parturition; however, the underlying processes that contribute are largely unknown. Changes in both systemic and cardiac metabolism appear to be associated with cardiac g...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2023-05, Vol.38 (S1)
Main Authors: Schulman, Emily, Collins, Helen
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract only Introduction: During pregnancy, the maternal heart undergoes physiological cardiac growth, which reverses following parturition; however, the underlying processes that contribute are largely unknown. Changes in both systemic and cardiac metabolism appear to be associated with cardiac growth, which could also contribute during pregnancy. We have shown that several cardiac metabolic transcripts and proteins and liver-derived metabolites are elevated during pregnancy and postpartum and are associated with cardiac growth. Therefore, the goal of this study was to examine the extent to which the cardio-hepatic signaling axis contributes to pregnancy-induced cardiac growth and reversal. Methods and Results: Timed pregnancy studies in 12-week-old FVB/NJ mice revealed that both heart weight (HW:TL; p < 0.0001) and liver weight (LIV:TL; p
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.2023.38.S1.5732510