XX Sex Chromosome Complement in Female Mice is Obligatory for Vascular Function

Abstract only Biological sex plays an important role in cardiovascular disease (CVD) predisposition and incidence. Arterial stiffening assessed by pulse wave velocity is an independent marker for CVD and contributes to early vascular aging. Men have stiffer arteries than women, a sex difference that...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2023-05, Vol.38 (S1)
Main Authors: Sakamuri, Anil, Visniauskas, Bruna, Kilanowski-Doroh, Isabella, McNally, Alexandra, Imulinde-Sugi, Ariane, Lindsey, Sarah, Ogola, Benard
Format: Article
Language:English
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Summary:Abstract only Biological sex plays an important role in cardiovascular disease (CVD) predisposition and incidence. Arterial stiffening assessed by pulse wave velocity is an independent marker for CVD and contributes to early vascular aging. Men have stiffer arteries than women, a sex difference that is diminished with aging. Sex hormones are indicated to play a role in stiffening arteries but the role for sex chromosomes is unknown. To assess the role for sex hormones, sex chromosomes or their interaction we used four core genotype (FCG) mice (N=5-8/group). 2-Way ANOVA and Sidak’s multiple comparison test was used for statistical analysis and P
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.2023.38.S1.5734396