Sex differences in soluble (pro)renin receptor regulation of blood pressure

Abstract only Background: Cleavage of the extra-cellular domain of the (pro)renin receptor (PRR) yields a soluble fragment (sPRR), that has been implicated in the pathogenesis of hypertension. We recently developed a novel mouse model with mutation in the cleavage site of the PRR using CRISPR/Cas9 s...

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Published in:Physiology (Bethesda, Md.) Md.), 2023-05, Vol.38 (S1)
Main Authors: Gopinath, Dhruvan, Stuart, Deborah, Wheatley, Will, Symons, J, Ramkumar, Nirupama
Format: Article
Language:English
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Summary:Abstract only Background: Cleavage of the extra-cellular domain of the (pro)renin receptor (PRR) yields a soluble fragment (sPRR), that has been implicated in the pathogenesis of hypertension. We recently developed a novel mouse model with mutation in the cleavage site of the PRR using CRISPR/Cas9 such that sPRR is not generated. Since the gene encoding PRR is on the X-chromosome, male mutant mice have markedly lower plasma sPRR levels (control: 21.5 ± 2.5 vs mutant: 0.2 ± 0.03 ng/ml, p
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.2023.38.S1.5735305