Endocytosis of Polypeptides in Rabbit Nasal Respiratory Mucosa

D Cremaschi, C Porta and R Ghirardelli The nasal respiratory mucosa of the rabbit has a leaky epithelium actively transporting polypeptides by a specific transcytosis probably involved in sampling antigens. The transfer displays saturation kinetics and is abolished by metabolic inhibitors, actin fil...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 1997-10, Vol.12 (5), p.219-225
Main Authors: Cremaschi, D, Porta, C, Ghirardelli, R
Format: Article
Language:English
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Summary:D Cremaschi, C Porta and R Ghirardelli The nasal respiratory mucosa of the rabbit has a leaky epithelium actively transporting polypeptides by a specific transcytosis probably involved in sampling antigens. The transfer displays saturation kinetics and is abolished by metabolic inhibitors, actin filamet and microtubule disassemblers, inhibitors of vesicle fusion, and receptor recycling;it accepts polypeptide-covered but not uncovered nanoparticles.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiologyonline.1997.12.5.219