Peptide Hormone Regulation of Angiogenesis

Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, Qro., México It is now apparent that regulation of blood vessel growth contributes to the classical actions of hormones on development, growth, and reproduction. Endothelial cells are ideally posi...

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Bibliographic Details
Published in:Physiological reviews 2009-10, Vol.89 (4), p.1177-1215
Main Authors: Clapp, Carmen, Thebault, Stephanie, Jeziorski, Michael C, Martinez De La Escalera, Gonzalo
Format: Article
Language:English
Subjects:
Anatomy & physiology
Angiogenesis
Animals
Blood vessels
Female
Hormones
Humans
Neovascularization, Pathologic - physiopathology
Neovascularization, Physiologic - physiology
Peptide Hormones - physiology
Peptide Hydrolases - metabolism
Peptides
Pregnancy
Reproduction - physiology
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Summary:Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, Qro., México It is now apparent that regulation of blood vessel growth contributes to the classical actions of hormones on development, growth, and reproduction. Endothelial cells are ideally positioned to respond to hormones, which act in concert with locally produced chemical mediators to regulate their growth, motility, function, and survival. Hormones affect angiogenesis either directly through actions on endothelial cells or indirectly by regulating proangiogenic factors like vascular endothelial growth factor. Importantly, the local microenvironment of endothelial cells can determine the outcome of hormone action on angiogenesis. Members of the growth hormone/prolactin/placental lactogen, the renin-angiotensin, and the kallikrein-kinin systems that exert stimulatory effects on angiogenesis can acquire antiangiogenic properties after undergoing proteolytic cleavage. In view of the opposing effects of hormonal fragments and precursor molecules, the regulation of the proteases responsible for specific protein cleavage represents an efficient mechanism for balancing angiogenesis. This review presents an overview of the actions on angiogenesis of the above-mentioned peptide hormonal families and addresses how specific proteolysis alters the final outcome of these actions in the context of health and disease.
ISSN:0031-9333
1522-1210
DOI:10.1152/physrev.00024.2009