The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk

Helicobacter pylori infects half of the world's population, and is associated with asymptomatic gastritis and also with more serious conditions such as peptic ulcer disease and gastric carcinoma. The clinical outcome is largely dependent on the severity and distribution of the H pylori-induced...

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Bibliographic Details
Published in:Canadian journal of gastroenterology 2003, Vol.17 Suppl B (B), p.8B-12B
Main Authors: Troost, Esther, Hold, Georgina L, Smith, Malcolm G, Chow, Wong-Ho, Rabkin, Charles S, McColl, Kenneth E L, El-Omar, Emad M
Format: Article
Language:English
Subjects:
Diet
Duodenal Ulcer - genetics
Environmental Exposure
Gastritis - genetics
Genetic Markers - genetics
Helicobacter Infections - complications
Helicobacter Infections - genetics
Helicobacter pylori - pathogenicity
Humans
Interleukin-1 - genetics
Multigene Family
Polymorphism, Genetic
Risk Factors
Sex Factors
Stomach Neoplasms - etiology
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Summary:Helicobacter pylori infects half of the world's population, and is associated with asymptomatic gastritis and also with more serious conditions such as peptic ulcer disease and gastric carcinoma. The clinical outcome is largely dependent on the severity and distribution of the H pylori-induced gastritis, but the pathogenesis remains poorly understood. Bacterial virulence factors and environmental influences contribute to the pathogenesis, but do not explain the divergent outcomes. There is emerging evidence that host genetic factors play a key role in determining the clinical outcome of H pylori infection. In particular, proinflammatory genotypes of the interleukin-1 beta (IL-1b) gene are associated with an increased risk of gastric cancer and its precursors. The effects are most likely mediated through the induction of hypochlorhydria and severe corpus gastritis with the subsequent development of gastric atrophy. The roles of IL-1b and other host genetic factors in the pathogenesis of H pylori related cancer are discussed in this article.
ISSN:0835-7900
2291-2789
2291-2797
DOI:10.1155/2003/397060