Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity

A series of Compound 4‐(2᾽‐hydroxy‐3᾽‐chloro‐5᾽‐ethyl phen‐1᾽‐yl)‐1‐(4᾽‐tolyl)‐3‐chloro‐2‐azetidinone 4a‐j have been prepared by the reaction of 2 ‐hydroxy‐3 ‐chloro‐5 ‐ethyl‐N‐(p‐tolyl)‐chalconimines 3a‐j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a‐j...

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Bibliographic Details
Published in:E-journal of chemistry 2004-01, Vol.1 (5), p.272-275
Main Authors: Vashi, Kamal, Naik, H. B.
Format: Article
Language:English
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Summary:A series of Compound 4‐(2᾽‐hydroxy‐3᾽‐chloro‐5᾽‐ethyl phen‐1᾽‐yl)‐1‐(4᾽‐tolyl)‐3‐chloro‐2‐azetidinone 4a‐j have been prepared by the reaction of 2 ‐hydroxy‐3 ‐chloro‐5 ‐ethyl‐N‐(p‐tolyl)‐chalconimines 3a‐j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a‐j has been prepared by the condensation of different substituted chalone derivatives 1 with p‐toluidine 2. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Escherichia coli .
ISSN:2090-9063
0973-4945
2090-9071
2090-9810
DOI:10.1155/2004/158924