High Performance Thin Layer Chromatographic Method for Estimation of Cefprozil in Tablet Dosage Form

A simple, fast, specific and precise HPTLC method has been developed for the estimation of cefprozil in pure and in tablet dosage forms. Aluminium plates precoated with silica gel G60F 254 were used as stationary phase and a mixture of chloroform: methanol: toluene: diethyl amine: water in the ratio...

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Bibliographic Details
Published in:E-journal of chemistry 2008, Vol.5 (3), p.427-430
Main Authors: Jagapathi Raju, V., Seshagiri Rao, J. V. L. N.
Format: Article
Language:English
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Summary:A simple, fast, specific and precise HPTLC method has been developed for the estimation of cefprozil in pure and in tablet dosage forms. Aluminium plates precoated with silica gel G60F 254 were used as stationary phase and a mixture of chloroform: methanol: toluene: diethyl amine: water in the ratio 4: 4.4: 3.2: 3: 0.8 v/v as mobile phase. Quantification was carried out by the use of a densitometer in absorbance mode at 286 nm. The R f value of cefprozil was found to be between 0.37 and 0.40. The results of the analysis have been validated statistically and by recovery studies. Linearity was observed in the concentration range of 400‐2000 ng/spot.
ISSN:2090-9063
0973-4945
2090-9071
2090-9810
DOI:10.1155/2008/197218