Protective Effect of Dodonaea viscosa (L) Against Lead Acetate Induced Altered Glycoprotein Profiles in Rats

The present study was undertaken to examine the inhibitory effect of crude leaves of Dodonaea viscosa (L) on lead acetate induced synthesis of glycoproteins and sialic acid in liver and plasma. Enhanced synthesis of glycoproteins (protein ‐ bound hexose and protein ‐ bound hexosamine) and sialic aci...

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Bibliographic Details
Published in:E-journal of chemistry 2009, Vol.6 (3), p.725-728
Main Authors: Sivanesan, D., Selvi, A. V. Veera Thamarai, Bhakyaraj, R., Arunachalam, T.
Format: Article
Language:English
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Summary:The present study was undertaken to examine the inhibitory effect of crude leaves of Dodonaea viscosa (L) on lead acetate induced synthesis of glycoproteins and sialic acid in liver and plasma. Enhanced synthesis of glycoproteins (protein ‐ bound hexose and protein ‐ bound hexosamine) and sialic acid levels were found in liver and plasma of the lead acetate poisoned rats. Administration of crude leaves of D.viscosa (100 mg/100 g body weight P.O.) effectively suppressed the synthesis of glycoproteins and sialic acid in liver and thereby controlling the concentration in plasma. The results suggest that D.viscosa may exert its membrane protection effect by inhibiting the synthesis of glycoproteins and sialic acid induced by lead acetate.
ISSN:2090-9063
0973-4945
2090-9071
2090-9810
DOI:10.1155/2009/294794