Estimation of Lamotrigine by RP‐HPLC Method

A rapid and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of lamotrigine in its pure form as well as in pharmaceutical dosage forms. Chromatography was carried out on a Luna C 18 column using a mixture of potassium dihydrogen phosphat...

Full description

Saved in:
Bibliographic Details
Published in:E-journal of chemistry 2010, Vol.7 (S1), p.S203-S208
Main Authors: Anantha Kumar, D., Venkata Kumar, CH, Seetharamaiah, P., Seshagiri Rao, J. V. L. N.
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A rapid and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of lamotrigine in its pure form as well as in pharmaceutical dosage forms. Chromatography was carried out on a Luna C 18 column using a mixture of potassium dihydrogen phosphate buffer (pH 7.3) and methanol in a ratio of 60:40 v/v as the mobile phase at a flow rate of 1.0 mL/min. The detection was done at 305 nm. The retention time of the drug was 6.1 min. The method produced linear responses in the concentration range of 10 to 70 μg/mL of lamotrigine. The method was found to be reproducible for analysis of the drug in tablet dosage forms.
ISSN:2090-9063
0973-4945
2090-9071
2090-9810
DOI:10.1155/2010/754745