Cerebral perfusion in chronic stroke: implications for lesion-symptom mapping and functional MRI

Lesion-symptom mapping studies are based upon the assumption that behavioral impairments are directly related to structural brain damage. Given what is known about the relationship between perfusion deficits and impairment in acute stroke, attributing specific behavioral impairments to localized bra...

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Bibliographic Details
Published in:Behavioural neurology 2011, Vol.24 (2), p.117-122
Main Authors: Richardson, Jessica D, Baker, Julie M, Morgan, Paul S, Rorden, Chris, Bonilha, L, Fridriksson, Julius
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brain - blood supply
Brain - physiopathology
Brain Ischemia - physiopathology
Brain Mapping
Cerebrovascular Circulation
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Spin Labels
Stroke - physiopathology
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Summary:Lesion-symptom mapping studies are based upon the assumption that behavioral impairments are directly related to structural brain damage. Given what is known about the relationship between perfusion deficits and impairment in acute stroke, attributing specific behavioral impairments to localized brain damage leaves much room for speculation, as impairments could also reflect abnormal neurovascular function in brain regions that appear structurally intact on traditional CT and MRI scans. Compared to acute stroke, the understanding of cerebral perfusion in chronic stroke is far less clear. Utilizing arterial spin labeling (ASL) MRI, we examined perfusion in 17 patients with chronic left hemisphere stroke. The results revealed a decrease in left hemisphere perfusion, primarily in peri-infarct tissue. There was also a strong relationship between increased infarct size and decreased perfusion. These findings have implications for lesion-symptom mapping studies as well as research that relies on functional MRI to study chronic stroke.
ISSN:0953-4180
1875-8584
DOI:10.1155/2011/380810