Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5‐Dimethylfuran Moiety

A series of new chalcones (3a-g) were prepared by Claisen‐Schmidt condensation of 3‐acetyl‐2,5‐dimethylfuran with various substituted aromatic aldehydes in presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized chalcones were characterized by means of th...

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Bibliographic Details
Published in:E-journal of chemistry 2011, Vol.8 (2), p.541-546
Main Authors: Sridhar, S., Dinda, S. C., Prasad, Y. Rajendra
Format: Article
Language:English
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Summary:A series of new chalcones (3a-g) were prepared by Claisen‐Schmidt condensation of 3‐acetyl‐2,5‐dimethylfuran with various substituted aromatic aldehydes in presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized chalcones were characterized by means of their IR, 1 H NMR spectral data and elemental analyses. When these chalcones were evaluated for antimicrobial and anti‐inflammatory activities, some of them were found to possess significant activity, when compared to standard drugs.
ISSN:2090-9063
0973-4945
2090-9071
2090-9810
DOI:10.1155/2011/582603