Association of CD28 IVS3 +17T/C polymorphism with soluble CD28 in rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved in T cell presentation. The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to R...

Full description

Saved in:
Bibliographic Details
Published in:Disease markers 2011, Vol.30 (1), p.25-29
Main Authors: Ledezma-Lozano, I Y, Padilla-Martínez, J J, Leyva-Torres, S D, Parra-Rojas, I, Ramírez-Dueñas, M G, Pereira-Suárez, Ana Laura, Rangel-Villalobos, H, Ruiz-Quezada, S L, Sánchez-Hernández, P E, Muñoz-Valle, J F
Format: Article
Language:English
Subjects:
Adult
Arthritis, Rheumatoid - genetics
Case-Control Studies
CD28 Antigens - blood
CD28 Antigens - genetics
Female
Gene Frequency
Genetic Association Studies
Genotype
Humans
Introns
Male
Mexico
Middle Aged
Polymorphism, Single Nucleotide
Young Adult
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved in T cell presentation. The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas the soluble concentrations of CD28 (sCD28) could be related to clinical activity. We investigated the CD28 IVS3 +17T/C polymorphism in 200 RA patients and 200 healthy subjects (HS). Furthermore, we quantified the sCD28 concentrations in 77 samples of each group. We applied indexes focused to determine the activity and disability (DAS28 and Spanish HAQ-DI, respectively) in RA patients. RA patients had significantly higher frequencies of the CD28 T allele compared to HS (p = 0.032 OR = 1.59, C.I. 1.02-2.49). In addition, the IVS3 +17 T/T genotype frequency was also increased in RA vs. HS (p = 0.026). The RA patients showed higher sCD28 serum levels than HS (p = 0.001). Carriers of the T/T genotype in RA patients showed higher sCD28 levels than C/C carriers (p =0.047). In addition, a correlation between sCD28 and Spanish HAQ-DI (correlation, 0.272; p =0.016), was found. The T allele in CD28 IVS3 +17T/C polymorphism is associated with a susceptibility to RA in Western Mexico. In addition, increased sCD28 levels are related to T/T genotype in RA patients.
ISSN:0278-0240
1875-8630
DOI:10.1155/2011/620849