Synthesis and In Vitro Cytotoxic Activity of N ‐2‐(2‐Furyl)‐2‐(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives

Quinolone are a class of potent broad‐spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N ‐pipearzinyl quinolones containing N ‐2‐(furyl‐2...

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Published in:E-journal of chemistry 2011, Vol.8 (3), p.1226-1231
Main Authors: Alipour, Eskandar, Hosseini, Negar Mohammad, Panah, Fatemeh, Ardestani, Sussan K., Safavi, Maliheh, Shafiee, Abbas, Foroumadi, Alireza
Format: Article
Language:English
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Summary:Quinolone are a class of potent broad‐spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N ‐pipearzinyl quinolones containing N ‐2‐(furyl‐2‐yl)‐2‐(chlorobenzyloxyimino) ethyl moiety (6a-c) have been studied. Preliminary screening showed that one of the new compounds, namely 7‐(4‐(2‐(3‐chlorobenzyloxyimino)‐2‐(furan‐2‐yl) ethyl) piperazin‐1‐yl)‐1‐cyclopropyl‐6‐fluoro‐4‐oxo‐1, 4‐dihydroquinoline‐3‐carboxylic acid (6b) showed significant cytotoxic activity against human breast tumor cell lines.
ISSN:2090-9063
0973-4945
2090-9071
2090-9810
DOI:10.1155/2011/842982