Synthesis and In Vitro Cytotoxic Activity of N ‐2‐(2‐Furyl)‐2‐(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives

Quinolone are a class of potent broad‐spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N ‐pipearzinyl quinolones containing N ‐2‐(furyl‐2...

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Published in:E-journal of chemistry 2011, Vol.8 (3), p.1226-1231
Main Authors: Alipour, Eskandar, Hosseini, Negar Mohammad, Panah, Fatemeh, Ardestani, Sussan K., Safavi, Maliheh, Shafiee, Abbas, Foroumadi, Alireza
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container_end_page 1231
container_issue 3
container_start_page 1226
container_title E-journal of chemistry
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creator Alipour, Eskandar
Hosseini, Negar Mohammad
Panah, Fatemeh
Ardestani, Sussan K.
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Shafiee, Abbas
Foroumadi, Alireza
description Quinolone are a class of potent broad‐spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N ‐pipearzinyl quinolones containing N ‐2‐(furyl‐2‐yl)‐2‐(chlorobenzyloxyimino) ethyl moiety (6a-c) have been studied. Preliminary screening showed that one of the new compounds, namely 7‐(4‐(2‐(3‐chlorobenzyloxyimino)‐2‐(furan‐2‐yl) ethyl) piperazin‐1‐yl)‐1‐cyclopropyl‐6‐fluoro‐4‐oxo‐1, 4‐dihydroquinoline‐3‐carboxylic acid (6b) showed significant cytotoxic activity against human breast tumor cell lines.
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title Synthesis and In Vitro Cytotoxic Activity of N ‐2‐(2‐Furyl)‐2‐(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives
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