Synthesis and Characterization of New Amino Acid‐Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes ( In Vitro )

• Published in: E-journal of chemistry 2012-01, Vol.9 (2), p.962-969
• Main Authors: Al-Garawi, Zahraa Salim M., Tomi, Ivan Hameed R., Al-Daraji, Ali Hussein R.
• Format: Article
• Language: English
• ISSN: 2090-9063; 0973-4945; 2090-9071; 2090-9810
• DOI: 10.1155/2012/218675

In this study, two new Schiff base compounds derived from the condensation reaction of L ‐glycine and L ‐tryptophan with 4‐methylbenzal‐dehyde have been synthesized. The Schiff base compounds were characterized by FT‐IR, UV and 1 H NMR spectroscopy. Their effects on the activity of total (ACP), prostatic (PAP) and non prostatic (NPA) acid phosphatase enzymes were studied. The Schiff base derived from L ‐glycine (A) demonstrated inhibition effect on the ACP and NPA activities and activation effect on PAP activity. The Schiff base derived from L ‐tryptophan (B) demonstrated semi fixed inhibition effects on the ACP and NPA activities at high concentrations (5.5×10 -2 , 5.5×10 -3 and 5.5×10 -4 M) and activator effect at low concentration (5.5×10 -5 M) while it was exhibits as activator on PAP activity.