Room Temperature N-Arylation of 1,2,4-Triazoles under Ligand-Free Condition

A simple and efficient method for N-arylation of 1,2,4-triazole at room temperature was described by the use of predominant (111) facet CuO nanoparticles as a catalyst in ligand-free condition. The catalyst was recyclable, and a variety of substrates give N-arylation product in high yield with short...

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Bibliographic Details
Published in:Organic chemistry International 2012-11, Vol.2012, p.1-7
Main Authors: Suramwar, Nikhil V., Thakare, Sanjay R., Khaty, Niraj T.
Format: Article
Language:English
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Summary:A simple and efficient method for N-arylation of 1,2,4-triazole at room temperature was described by the use of predominant (111) facet CuO nanoparticles as a catalyst in ligand-free condition. The catalyst was recyclable, and a variety of substrates give N-arylation product in high yield with short period of reaction time. The wide scope of this catalyst led us to investigate transformations involving less-reactive nitrogen nucleophiles, such as imidazole and pyrazoles. We were pleased to find that various derivatives of azoles were effectively coupled with aryl iodide to afford the desired N-arylated product in excellent yield.
ISSN:2090-200X
2090-2018
DOI:10.1155/2012/515092