Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1‐(5,7‐Dichloro‐1,3‐benzoxazol‐2‐yl)‐1 H ‐pyrazolo[3,4‐b]quinoline Derivatives

Some novel 1‐(5,7‐dichloro‐1,3‐benzoxazol‐2‐yl)‐1 H ‐pyrazolo[3,4‐ b ]quinoline derivatives 8 ( a–f ) were synthesized by reacting 5,7‐dichloro‐2‐hydrazino‐1,3‐benzoxazole 4 and substituted‐2‐chloro‐3‐quinoline carbaldehydes using p ‐toluenesulfonic acid (PTSA) as a catalyst for the cyclisation. The...

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Published in:Journal of chemistry 2013-01, Vol.2013 (1)
Main Authors: Jayanna, N. D., Vagdevi, H. M., Dharshan, J. C., Kekuda, T. R. Prashith
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description Some novel 1‐(5,7‐dichloro‐1,3‐benzoxazol‐2‐yl)‐1 H ‐pyrazolo[3,4‐ b ]quinoline derivatives 8 ( a–f ) were synthesized by reacting 5,7‐dichloro‐2‐hydrazino‐1,3‐benzoxazole 4 and substituted‐2‐chloro‐3‐quinoline carbaldehydes using p ‐toluenesulfonic acid (PTSA) as a catalyst for the cyclisation. The target molecules have been characterized by IR, 1 H NMR, 13 C NMR, and mass spectral studies. The synthesized compounds were screened for biological activities, and some of the compounds have exhibited encouraging antibacterial and antioxidant activities. The compounds 8a and 8e showed potent antibacterial activity, whereas the compounds 8e and 8f act as antioxidants.
doi_str_mv 10.1155/2013/234074
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title Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1‐(5,7‐Dichloro‐1,3‐benzoxazol‐2‐yl)‐1 H ‐pyrazolo[3,4‐b]quinoline Derivatives
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