Utility of OCT3/4, TSPY and β-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads

Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor. Determine whether OCT3/4 and β-catenin are expressed in dysgenetic gonads before GB development and whether TSPY participates in the OCT3/4-β...

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Bibliographic Details
Published in:Disease markers 2013, Vol.34 (6), p.419-424
Main Authors: Palma, Icela, Garibay, Nayely, Pena-Yolanda, Rocio, Contreras, Alejandra, Raya, Atlantida, Dominguez, Carolina, Romero, Mirna, Aristi, Gerardo, Queipo, Gloria
Format: Article
Language:English
Subjects:
beta Catenin - analysis
Biomarkers, Tumor - analysis
Case-Control Studies
Cell Cycle Proteins - analysis
Child
Dysgerminoma - diagnosis
Gonadal Dysgenesis - diagnosis
Gonadoblastoma - diagnosis
Humans
Neoplasms, Gonadal Tissue - diagnosis
Octamer Transcription Factor-3 - analysis
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Summary:Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor. Determine whether OCT3/4 and β-catenin are expressed in dysgenetic gonads before GB development and whether TSPY participates in the OCT3/4-β-catenin pathways in the malignant invasive behavior. dysgenetic gonads of Disorders of sex differentiation (DSD) patients with mixed gonadal dysgenesis were analyzed by immunohistochemistry and immunofluorescence for comparison with GB and dysgerminoma/seminoma. Our results suggest that the development of GB is secondary to the interaction of OCT3/4 and TSPY, that β-catenin does not participate in this process. The use of this biological markers detects the potential high risk gonads.
ISSN:0278-0240
1875-8630
DOI:10.1155/2013/951751